Your browser doesn't support javascript.
loading
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance.
Bhat, Gh Rasool; Sethi, Itty; Sadida, Hana Q; Rah, Bilal; Mir, Rashid; Algehainy, Naseh; Albalawi, Ibrahim Altedlawi; Masoodi, Tariq; Subbaraj, Gowtham Kumar; Jamal, Farrukh; Singh, Mayank; Kumar, Rakesh; Macha, Muzafar A; Uddin, Shahab; Akil, Ammira S Al-Shabeeb; Haris, Mohammad; Bhat, Ajaz A.
Afiliación
  • Bhat GR; Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
  • Sethi I; Institute of Human Genetics, University of Jammu, Jammu, Jammu and Kashmir, India.
  • Sadida HQ; Department of Human Genetics-Precision Medicine in Diabetes, Obesity and Cancer Program, Sidra Medicine, Doha, Qatar.
  • Rah B; Iron Biology Group, Research Institute of Medical and Health Science, University of Sharjah, Sharjah, UAE.
  • Mir R; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
  • Algehainy N; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
  • Albalawi IA; Department of Surgical Oncology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
  • Masoodi T; Laboratory of Cancer Immunology and Genetics, Sidra Medicine, Doha, Qatar.
  • Subbaraj GK; Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India.
  • Jamal F; Dr. Rammanohar, Lohia Avadh University, Ayodhya, India.
  • Singh M; Department of Medical Oncology (Lab.), Institute of Medical Sciences (AIIMS), Dr. BRAIRCH, All India, New Delhi, India.
  • Kumar R; School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India.
  • Macha MA; Watson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, Awantipora, Jammu and Kashmir, India.
  • Uddin S; Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
  • Akil ASA; Laboratory Animal Research Centre, Qatar University, Doha, Qatar.
  • Haris M; Department of Human Genetics-Precision Medicine in Diabetes, Obesity and Cancer Program, Sidra Medicine, Doha, Qatar.
  • Bhat AA; Laboratory Animal Research Centre, Qatar University, Doha, Qatar. mohammad.haris@pennmedicine.upenn.edu.
Cancer Metastasis Rev ; 43(1): 197-228, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38329598
ABSTRACT
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. Cancer cell plasticity is intertwined with processes such as epithelial-mesenchymal transition and the acquisition of stem cell-like features. These processes are pivotal in the development and progression of tumors, contributing to the multifaceted nature of cancer and the challenges associated with its treatment. Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. Our review delves into the array of mechanisms cancer cells exploit to maintain plasticity, including epigenetic modifications, alterations in signaling pathways, and environmental interactions. We discuss strategies to counteract cancer cell plasticity, such as targeting specific cellular pathways and employing combination therapies. These strategies promise to enhance the efficacy of cancer treatments and mitigate therapy resistance. In conclusion, this review offers a holistic, detailed exploration of cancer cell plasticity, aiming to bolster the understanding and approach toward tackling the challenges posed by tumor heterogeneity and drug resistance. As articulated in this review, the delineation of cellular, molecular, and genetic mechanisms underlying tumor heterogeneity and drug resistance seeks to contribute substantially to the progress in cancer therapeutics and the advancement of precision medicine, ultimately enhancing the prospects for effective cancer treatment and patient outcomes.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasticidad de la Célula / Neoplasias Límite: Humans Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasticidad de la Célula / Neoplasias Límite: Humans Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos