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A Smart Skin for Hydrogels That Enables Switchable Solute Release.
Subraveti, Sai Nikhil; Peters, Sebastian M; Nader, Morine G; Burni, Faraz A; Raghavan, Srinivasa R.
Afiliación
  • Subraveti SN; Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
  • Peters SM; Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
  • Nader MG; Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
  • Burni FA; Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
  • Raghavan SR; Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.
ACS Appl Mater Interfaces ; 16(7): 9201-9209, 2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38329464
ABSTRACT
Many applications of hydrogels rely on their ability to deliver encapsulated solutes, such as drugs; however, small hydrophilic solutes rapidly leak out of gels by diffusion. A need exists for a way to regulate solute release out of gels─to ensure zero release until a desired time (the OFF state) and thereafter for the release to be switched ON at a high rate. This should ideally be a repeatable switch; i.e., the gel should be cyclable repeatedly between the ON and OFF states. Such perfect, cyclical ON-OFF release of solutes from gels is demonstrated for the first time through a "smart skin" that is synthesized rapidly (in ∼10 min) around an entire gel. The thin (∼100 µm) and transparent polymer skin is endowed with redox-responsive properties through the use of urethane and acrylate monomers, one of which contains a thioether group. Initially, the skin is hydrophobic (water contact angle 102°), and it completely prevents hydrophilic solutes from leaking out of the gel. When contacted with oxidants such as hydrogen peroxide (H2O2), the thioethers are converted to sulfoxides, making the skin hydrophilic (water contact angle 42°) and thereby turning ON the release of solutes. Conversely, solute release can be turned OFF subsequently by adding a reducing agent such as vitamin C that reverts the sulfoxides to thioethers and thus returns the skin to its hydrophobic state. The release rate in the ON state can be tuned via the skin thickness as well as the oxidant concentration. The ability to regulate solute delivery from gels using smart skins is likely to prove significant in areas ranging from separations to agriculture and drug delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Peróxido de Hidrógeno Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Peróxido de Hidrógeno Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos