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Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population.
Männistö, Ville T; Hakkarainen, Konsta; Jula, Antti; Lundqvist, Annamari; Vihervaara, Terhi; Erlund, Iris; Åberg, Fredrik.
Afiliación
  • Männistö VT; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
  • Hakkarainen K; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
  • Jula A; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
  • Lundqvist A; Finnish Institute for Health and Welfare, Finland.
  • Vihervaara T; Finnish Institute for Health and Welfare, Finland.
  • Erlund I; Finnish Institute for Health and Welfare, Finland.
  • Åberg F; Finnish Institute for Health and Welfare, Finland.
Scand J Gastroenterol ; 59(5): 592-599, 2024 May.
Article en En | MEDLINE | ID: mdl-38329447
ABSTRACT
BACKGROUND &

AIMS:

Hyperferritinemia reflects iron accumulation in the body and has been associated with metabolic disturbances and alcohol use, and is also a common finding in individuals diagnosed with liver disease. The major genetic regulator of iron metabolism is the HFE gene.

METHODS:

The aim of this this study was to investigate the association between serum ferritin and liver fibrosis using the enhanced liver fibrosis (ELF) test, and the association between ferritin and liver-related outcomes in a Finnish population-based cohort of 6194 individuals (45% male, mean [± standard deviation] age, 52.9 ± 14.9 years; body mass index 26.9 ± 4.7 kg/m2). The effects of HFE variants on these associations were also evaluated.

RESULTS:

Serum ferritin levels were significantly associated with liver fibrosis, as estimated by enhanced liver fibrosis (ELF) test in weighted linear regression analysis. Serum ferritin was significantly associated with both all liver-related outcomes (n = 92) and severe liver-related outcomes (n = 54) in weighted Cox regression analysis (hazard ratio [HR] per 1 SD, 1.11 [95% confidence interval (CI) 1.02-1.21]; p = 0.012 and HR 1.11 [95% CI 1.02-1.21]; p = 0.013, respectively). However, there was association neither between HFE risk variants and ELF test nor between HFE risk variants and liver-related outcomes.

CONCLUSION:

Serum ferritin levels were associated with liver fibrosis and incident liver disease, independent of HFE genotype in the general population. Furthermore, data demonstrated that metabolic disturbances and alcohol use were major risk factors for hyperferritinemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ferritinas / Proteína de la Hemocromatosis / Genotipo / Cirrosis Hepática Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Scand J Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ferritinas / Proteína de la Hemocromatosis / Genotipo / Cirrosis Hepática Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Scand J Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido