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Diastolic Dysfunction as a Positive Predictor of Recurrent Vascular Events in Patients With Noncardioembolic Stroke.
Ishizuka, Kentaro; Hoshino, Takao; Mizuno, Takafumi; Takahashi, Shuntaro; Wako, Sho; Arai, Satoko; Toi, Sono; Kitagawa, Kazuo.
Afiliación
  • Ishizuka K; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Hoshino T; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Mizuno T; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Takahashi S; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Wako S; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Arai S; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Toi S; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
  • Kitagawa K; Department of Neurology, Tokyo Women's Medical University School of Medicine, Japan.
Stroke ; 55(3): 595-603, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38328918
ABSTRACT

BACKGROUND:

This study aimed to assess the effects of left ventricular diastolic dysfunction (LVDD) on vascular outcomes among patients with stroke of noncardioembolic origins.

METHODS:

This prospective observational study enrolled 563 patients with noncardioembolic stroke (mean age, 67.9 years; 66.7% men and 33.3% women individuals) registered in the Tokyo Women's Medical University Stroke Registry between 2013 and 2020. Then, patients were divided into the LVDD and non-LVDD groups. The primary outcome was a composite of major adverse cardiovascular events, including nonfatal stroke, nonfatal acute coronary syndrome, and vascular death 1 year after stroke onset. The effect of LVDD on vascular events was assessed using multivariable Cox regression analyses.

RESULTS:

A total of 130 (23.1%) patients had any grade of LVDD, and patients with LVDD had a higher risk of major adverse cardiovascular event at 1 year than those without LVDD (annual rate, 20.9% versus 10.8%; log-rank P=0.001). The multivariable Cox proportional hazards regression model demonstrated that the presence of LVDD was independently associated with the major adverse cardiovascular event risk (hazard ratio, 1.79 [95% CI, 1.02-3.12]; P=0.019). Furthermore, the LVDD grade was proportional to the risk of major adverse cardiovascular events and recurrent stroke.

CONCLUSIONS:

LVDD may be associated with further vascular events after a noncardioembolic stroke, suggesting the importance of LVDD evaluations in risk stratification and secondary prevention in patients with noncardioembolic stroke. REGISTRATION URL https//upload.umin.ac.jp; Unique identifier UMIN000031913.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Síndrome Coronario Agudo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Stroke Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Síndrome Coronario Agudo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Stroke Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos