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Complexities in Adjuvant Endocrine Therapy for Breast Cancer in Female-to-Male Transgender Patients.
Sato, Shoko; Imada, Sae; Hayami, Ryosuke; Arai, Kazumori; Kosugi, Rieko; Tsuneizumi, Michiko; Matsunuma, Ryoichi.
Afiliación
  • Sato S; Department of Breast Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Imada S; Department of Breast Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Hayami R; Department of Breast Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Arai K; Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.
  • Kosugi R; Center for Diabetes, Endocrinology and Metabolism, Shizuoka General Hospital, Shizuoka, Japan.
  • Tsuneizumi M; Department of Breast Surgery, Shizuoka General Hospital, Shizuoka, Japan.
  • Matsunuma R; Department of Breast Surgery, Shizuoka General Hospital, Shizuoka, Japan.
Case Rep Oncol ; 17(1): 208-216, 2024.
Article en En | MEDLINE | ID: mdl-38327829
ABSTRACT

Introduction:

Managing breast cancer in female-to-male (FtM) transgender patients is complicated and challenging. Androgens play a crucial role in the development of secondary sexual identity in FtM transgender patients, but their effectiveness in breast cancer remains unclear. Furthermore, the considerations for adjuvant endocrine therapy in this population are highly intricate and warrant thorough discussion. Case Presentation We describe the case of a 44-year-old FtM transgender diagnosed with breast cancer 3 years after initiating androgen receptor agonist therapy as part of his gender identity transition. After mastectomy, adjuvant endocrine therapy was initiated, consisting of a combination of an aromatase inhibitor and a gonadotropin-releasing hormone agonist, along with a cross-sex hormone.

Conclusion:

Estradiol levels were significantly reduced, and male-typical levels of sex hormones were attained.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Case Rep Oncol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Case Rep Oncol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza