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Genome-wide transcriptional profiling and functional analysis of long noncoding RNAs and mRNAs in chicken macrophages associated with the infection of avian pathogenic E. coli.
Sun, Hongyan; Cao, Xinqi; Ma, Yuyi; Li, Huan; Han, Wei; Qu, Lujiang.
Afiliación
  • Sun H; College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. sunhy@yzu.edu.cn.
  • Cao X; College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
  • Sumayya; College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
  • Ma Y; College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
  • Li H; School of Biological and Chemical Engineering, Yangzhou Polytechnic College, Yangzhou, 225009, China.
  • Han W; The Poultry Research Institute of Chinese Academy of Agricultural Sciences, Yangzhou, 225009, China.
  • Qu L; College of Animal Science and Technology, China Agricultural University, Beijing, 100091, China.
BMC Vet Res ; 20(1): 49, 2024 Feb 07.
Article en En | MEDLINE | ID: mdl-38326918
ABSTRACT

BACKGROUND:

Avian pathogenic E. coli (APEC) can cause localized or systemic infections, collectively known as avian colibacillosis, resulting in huge economic losses to poultry industry globally per year. In addition, increasing evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in regulating host inflammation in response to bacterial infection. However, the role of lncRNAs in the host response to APEC infection remains unclear.

RESULTS:

Here, we found 816 differentially expressed (DE) lncRNAs and 1,798 DE mRNAs in APEC infected chicken macrophages by RNAseq. The identified DE lncRNA-mRNAs were involved in Toll like receptor signaling pathway, VEGF signaling pathway, fatty acid metabolism, phosphatidylinositol signaling system, and other types of O-glycan biosynthesis. Furthermore, we found the novel lncRNA TCONS_00007391 as an important immune regulator in APEC infection was able to regulate the inflammatory response by directly targeting CD86.

CONCLUSION:

These findings provided a better understanding of host response to APEC infection and also offered the potential drug targets for therapy development against APEC infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Infecciones por Escherichia coli / ARN Largo no Codificante Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Infecciones por Escherichia coli / ARN Largo no Codificante Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido