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Protective role of SARS-CoV-2 anti-S IgG against breakthrough infections among European healthcare workers during pre and post-Omicron surge-ORCHESTRA project.
Spiteri, Gianluca; D'Agostini, Marika; Abedini, Mahsa; Ditano, Giorgia; Collatuzzo, Giulia; Boffetta, Paolo; Vimercati, Luigi; Sansone, Emanuele; De Palma, Giuseppe; Modenese, Alberto; Gobba, Fabriziomaria; Liviero, Filippo; Moretto, Angelo; dell'Omo, Marco; Fiordi, Tiziana; Larese Filon, Francesca; Mauro, Marcella; Violán, Concepción; Mates, Dana; Oravec Béresová, Jana; Monaco, Maria Grazia Lourdes; Carta, Angela; Verlato, Giuseppe; Porru, Stefano.
Afiliación
  • Spiteri G; Occupational Medicine Unit, University Hospital of Verona, 37134, Verona, Italy.
  • D'Agostini M; Department of Medical and Surgical Sciences, University of Bologna, 40138, Bologna, Italy. marika.dagostini2@unibo.it.
  • Abedini M; Department of Medical and Surgical Sciences, University of Bologna, 40138, Bologna, Italy.
  • Ditano G; Department of Medical and Surgical Sciences, University of Bologna, 40138, Bologna, Italy.
  • Collatuzzo G; Department of Medical and Surgical Sciences, University of Bologna, 40138, Bologna, Italy.
  • Boffetta P; Department of Medical and Surgical Sciences, University of Bologna, 40138, Bologna, Italy.
  • Vimercati L; Interdisciplinary Department of Medicine, University of Bari, 70121, Bari, Italy.
  • Sansone E; Unit of Occupational Health and Industrial Hygiene, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121, Brescia, Italy.
  • De Palma G; Unit of Occupational Health and Industrial Hygiene, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121, Brescia, Italy.
  • Modenese A; Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25123, Brescia, Italy.
  • Gobba F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.
  • Liviero F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.
  • Moretto A; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128, Padua, Italy.
  • dell'Omo M; Occupational Medicine Unit, University Hospital of Padova, 35128, Padua, Italy.
  • Fiordi T; Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128, Padua, Italy.
  • Larese Filon F; Occupational Medicine Unit, University Hospital of Padova, 35128, Padua, Italy.
  • Mauro M; Department of Medicine and Surgery, University of Perugia, 06129, Perugia, Italy.
  • Violán C; Occupational Medicine Unit, Perugia Hospital, 06129, Perugia, Italy.
  • Mates D; Department of Medical Sciences, Unit of Occupational Medicine, University of Trieste, 34129, Trieste, Italy.
  • Oravec Béresová J; Department of Medical Sciences, Unit of Occupational Medicine, University of Trieste, 34129, Trieste, Italy.
  • Monaco MGL; Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303, Mataró, Barcelona, Spain.
  • Carta A; Germans Trias i Pujol Research Institute (IGTP), 08916, Badalona, Spain.
  • Verlato G; Grup de REcerca en Impacte de les Malalties Cròniques i les Seves Trajectòries (GRIMTra), (2021 SGR 01537), Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAPJGol), 08303, Barcelona, Spain.
  • Porru S; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) (RD21/0016/0029), Insitituto de Salud Carlos III, 28029, Madrid, Spain.
Infection ; 52(4): 1347-1356, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38326526
ABSTRACT

PURPOSE:

Anti SARS-CoV-2 vaccination initially showed high effectiveness in preventing COVID-19. However, after the surge of variants of concern, the effectiveness dropped. Several studies investigated if this was related to the decrease of the humoral response over time; however, this issue is still unclear. The aim of this study was to understand whether SARS-CoV-2 anti-S IgG levels can be used to predict breakthrough infection risk and define the timing for further booster doses administration.

METHOD:

Within the framework of the ORCHESTRA Project, over 20,000 health workers from 11 European centers were enrolled since December 2020. We performed two Cox proportional hazards survival analyses regarding pre-Omicron (from January to July 2021) and Omicron (December 2021-May 2022) periods. The serological response was classified as high (above the 75th percentile), medium (25th-75th), or low (< 25th).

RESULTS:

Seventy-four (0.33%) and 2122 (20%) health workers were infected during the first and second periods, respectively. Both Cox analyses showed that having high anti-S titer was linked to a significantly lower risk of infection as compared to having medium serological response [HR of high vs medium anti-S titer = 0.27 (95% CI 0.11-0.66) during the first phase, HR = 0.76 (95% CI 0.62-0.93) during the second phase].

CONCLUSION:

Vaccine effectiveness wanes significantly after new variants surge, making anti-S titer unsuitable to predict optimal timing for further booster dose administration. Studies on other immunological indicators, such as cellular immunity, are therefore needed to better understand the mechanisms and duration of protection against breakthrough infection risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Personal de Salud / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Infection Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Personal de Salud / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Infection Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania