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Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study.
Park, Sangwoo; Jeong, Seogsong; Park, Sun Jae; Song, Jihun; Kim, Sung Min; Chang, Jooyoung; Choi, Seulggie; Cho, Yoosun; Oh, Yun Hwan; Kim, Ji Soo; Park, Young Jun; Son, Joung Sik; Ahn, Joseph C; Park, Sang Min.
Afiliación
  • Park S; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
  • Jeong S; Department of Biomedical Informatics, CHA University School of Medicine, Seongnam, South Korea.
  • Park SJ; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
  • Song J; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
  • Kim SM; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
  • Chang J; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
  • Choi S; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
  • Cho Y; Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea.
  • Oh YH; Department of Family Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong-si, South Korea.
  • Kim JS; International Healthcare Center, Seoul National University Hospital, Seoul, Republic of Korea.
  • Park YJ; Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Son JS; Department of Family Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
  • Ahn JC; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
  • Park SM; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea. smpark.snuh@gmail.com.
Sci Rep ; 14(1): 3195, 2024 02 08.
Article en En | MEDLINE | ID: mdl-38326522
ABSTRACT
Although some studies conducted about the risk of cholecystectomy and cardiovascular disease, there was a limit to explaining the relationship. We investigated the short-term and long-term relationship between cholecystectomy and cardiovascular disease, and evidence using the elements of the metabolic index as an intermediate step. It was a retrospective cohort study and we used the National Health Insurance Service database of South Korea between 2002 and 2015. Finally, 5,210 patients who underwent cholecystectomy and 49,457 at 110 age and gender-matched controls of subjects were collected. The main results was estimated by Multivariate Cox proportional hazard regression to calculate the hazard ratio (HR) with 95% confidence interval (CI) for risk of cardiovascular disease after cholecystectomy. Regarding short-term effects of cholecystectomy, increased risk of cardiovascular disease (aHR 1.35, 95% CI 1.15-1.58) and coronary heart disease (aHR 1.77, 95% CI 1.44-2.16) were similarly seen within 2 years of surgery. When analyzing the change in metabolic risk factors, cholecystectomy was associated with a change in systolic blood pressure (adjusted mean [aMean] 1.51, 95% CI [- 1.50 to - 4.51]), total cholesterol (aMean - 14.14, [- 20.33 to 7.95]) and body mass index (aMean - 0.13, [- 0.37 to 0.11]). Cholecystectomy patients had elevated risk of cardiovascular disease in the short-term, possibly due to the characteristics of the patient before surgery. The association of cholecystectomy and cardiovascular disease has decreased after 2 years in patients who underwent cholecystectomy, suggesting that because of improvement of metabolic health, cholecystectomy-associated elevation of cardiovascular disease risk may be ameliorated 2 years after cholecystectomy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido