Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension.

Cookson, Michael W; Kinsella, John P

Cookson, Michael W; Kinsella, John P.

Afiliación

Cookson MW; Department of Pediatrics, Section of Neonatology, University of Colorado, Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO 80045, USA; Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO, USA. Electronic address: Michael.cookson@cuanschutz.edu.
Kinsella JP; Department of Pediatrics, Section of Neonatology, University of Colorado, Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO 80045, USA; Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.

Clin Perinatol ; 51(1): 95-111, 2024 03.

Article en En | MEDLINE | ID: mdl-38325949

ABSTRACT

ABSTRACT

Pivotal trials investigating the use of inhaled nitric oxide (iNO) in the 1990s led to approval by the Food and Drug Administration in 1999. Inhaled nitric oxide is the only approved pulmonary vasodilator for persistent pulmonary hypertension of the newborn (PPHN). Selective pulmonary vasodilation with iNO in near-term and term neonates with PPHN is safe, and targeted use of iNO in less mature neonates with pulmonary hypertension (PH) can be beneficial. This review addresses a brief history of iNO, clinical features of neonatal PH, and the clinical application of iNO.

Asunto(s)

Hipertensión Pulmonar; Síndrome de Circulación Fetal Persistente; Recién Nacido; Humanos; Óxido Nítrico/uso terapéutico; Hipertensión Pulmonar/tratamiento farmacológico; Administración por Inhalación; Síndrome de Circulación Fetal Persistente/tratamiento farmacológico; Pulmón

Palabras clave

Hypoxemic respiratory failure (HRF); Inhaled nitric oxide (iNO); Persistent pulmonary hypertension of the newborn (PPHN)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Circulación Fetal Persistente / Hipertensión Pulmonar Límite: Humans / Newborn Idioma: En Revista: Clin Perinatol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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