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Di (2-ethylhexyl) phthalate induced lipophagy-related renal ferroptosis in quail (Coturnix japonica).
Zhu, Yu; Ma, Xiang-Yu; Cui, Ling-Ge; Xu, Ya-Ru; Li, Chen-Xi; Talukder, Milton; Li, Xue-Nan; Li, Jin-Long.
Afiliación
  • Zhu Y; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Ma XY; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Cui LG; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Xu YR; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Li CX; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Talukder M; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Department of Physiology and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal 8210, Bangladesh.
  • Li XN; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laborator
  • Li JL; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laborator
Sci Total Environ ; 919: 170724, 2024 Apr 01.
Article en En | MEDLINE | ID: mdl-38325449
ABSTRACT
Di(2-ethylhexyl) phthalate (DEHP) is a synthetic chemical applied as a plasticizer. As an environmental toxicant, DEHP poses a serious health threat. Many studies have revealed that DEHP can cause lead to various degrees of damage to the kidney. However, the evidence of DEHP-induced renal ferroptosis has not been reported. The purpose of this work was to probe the specific role of lipophagy in DEHP-induced renal injury and to investigate the relationship between lipophagy and ferroptosis. Quail were treated with DEHP (250 mg/kg BW/day, 500 mg/kg BW/day and 750 mg/kg BW/day) for 45 days. Microstructural and ultrastructural observations showed that DEHP caused damage to glomerular and tubular cells, and autophagy with multilayer structures were observed, suggesting that DEHP can induce lipophagy. The results indicated that the iron homeostasis was abnormal and the lipid peroxidation was increased. SLC7A11 and SLC3A2 were down-regulated. PTGS2, ACSL4 and LPCAT3 were elevated. In conclusion, DEHP could induce lipid peroxidation, lead to ferroptosis, and damage renal cells. Therefore, the relationship between lipophagy and ferroptosis was elucidated, which provided a new basis for intervention and prevention of DEHP increased diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Dietilhexil Ftalato / Ferroptosis Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Dietilhexil Ftalato / Ferroptosis Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos