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Hypobaric type oxygenators - physics and physiology.
Chotimol, Phatiwat; Lansdowne, William; Machin, David; Binas, Kressle; Angelini, Gianni D; Gibbison, Ben.
Afiliación
  • Chotimol P; Department of Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Lansdowne W; Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
  • Machin D; Department of Anaesthesia,Bristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
  • Binas K; Department of Anaesthesia,Bristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
  • Angelini GD; Department of Anaesthesia,Bristol Heart Institute, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
  • Gibbison B; Department of Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Perfusion ; : 2676591241232824, 2024 Feb 07.
Article en En | MEDLINE | ID: mdl-38323543
ABSTRACT
Brain injury is still a serious complication after cardiac surgery. Gaseous microemboli (GME) are known to contribute to both short and longer-term brain injury after cardiac surgery. Hypobaric and novel dual-chamber oxygenators use the physical behaviors and properties of gases to reduce GME. The aim of this review was to present the basic physics of the gases, the mechanism in which the hypobaric and dual-chamber oxygenators reduce GME, their technical performance, the preclinical studies, and future directions. The gas laws are reviewed as an aid to understanding the mechanisms of action of oxygenators. Hypobaric-type oxygenators employ a high oxygen, no nitrogen environment creating a steep concentration gradient of nitrogen out of the blood and into the oxygenator, reducing the risk of GMEs forming. Adequately powered clinical studies have never been carried out with a hypobaric or dual-chamber oxygenator. These are required before such technology can be recommended for widespread clinical use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Perfusion Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Perfusion Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido