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Self-Assembly of Rod-Coil Bottlebrush Copolymers into Degradable Nanodiscs with a UV-Triggered Self-Immolation Process.
Zeng, Haoxiang; Liang, Xiaoli; Roberts, Derrick A; Gillies, Elizabeth R; Müllner, Markus.
Afiliación
  • Zeng H; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, 2006, Sydney, NSW, Australia.
  • Liang X; Department of Chemistry and Department of Chemical and Biochemical Engineering, The University of Western Ontario, N6A 5B7, London, Ontario, Canada.
  • Roberts DA; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, 2006, Sydney, NSW, Australia.
  • Gillies ER; Department of Chemistry and Department of Chemical and Biochemical Engineering, The University of Western Ontario, N6A 5B7, London, Ontario, Canada.
  • Müllner M; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, 2006, Sydney, NSW, Australia.
Angew Chem Int Ed Engl ; 63(13): e202318881, 2024 Mar 22.
Article en En | MEDLINE | ID: mdl-38320963
ABSTRACT
Polymer nanodiscs, especially with stimuli-responsive features, represent an unexplored frontier in the nanomaterial landscape. Such 2D nanomaterials are considered highly promising for advanced biomedicine applications. Herein, we designed a rod-coil copolymer architecture based on an amphiphilic, tadpole-like bottlebrush copolymer, which can directly self-assemble into core-shell nanodiscs in an aqueous environment. As the bottlebrush side chains are made of amorphous, UV-responsive poly(ethyl glyoxylate) (PEtG) chains, they can undergo rapid end-to-end self-immolation upon light irradiation. This triggered nanodisc disassembly can be used to boost small molecule release from the nanodisc core, which is further aided by a morphological change from discs to spheres.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania