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Analysis of the molecular alterations in cancer cells following nanotechnology-assisted targeted radiotherapy using Raman spectroscopy.
Jafarzadeh, Naser; Malekfar, Rasoul; Nadafan, Marzieh; Eynali, Samira; Koosha, Fereshteh; Satari, Mohammad.
Afiliación
  • Jafarzadeh N; Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: naser.jafarzadeh@modares.ac.ir.
  • Malekfar R; Atomic & Molecular Group, Department of Physics, Tarbiat Modares University, Tehran, Iran.
  • Nadafan M; Department of Physics, Shahid Rajaee Teacher Training University, Tehran, P. O. Box 16788-15811, Iran.
  • Eynali S; Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
  • Koosha F; Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: f.koosha@sbmu.ac.ir.
  • Satari M; Department of Biology, Faculty of Science, Malayer University, Malayer, Iran.
Appl Radiat Isot ; 206: 111223, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38320379
ABSTRACT
The study unveiled an innovative strategy for precise radiation targeting in cancer treatment, along with the monitoring of molecular changes induced by this therapeutic approach. In this research, we explored the impact of administering anti-HER2-AgNPs nanoconjugates either individually or in conjunction with gamma irradiation on the viability of SKBR3 breast cancer cells. The utilization of nanoconjugates resulted in an enhancement of cellular sensitivity toward radiation. The viability of the cells exhibited a decline as the dose of irradiation increased, and this decrease was further exacerbated by the passage of time following irradiation. The analysis of RS revealed distinct cellular responses in varying conditions. The observed increase in SERS intensity, resulting from the increment in dose from 0 to 2 Gy, can be attributed to the probable upregulation of HER2 expression induced by irradiation. The observed decrease in SERS intensity at doses of 4 and 6 Gy can be attributed to the likely reduction in HER2 expression. It was illustrated that the analysis of Raman spectroscopy data can aid in the identification of radiation-induced biochemical alterations in cancer cells during the application of nanoconjugates-based radiotherapy. The findings revealed that nanoconjugates have the potential to enhance cellular sensitivity to radiation along with facilitating the detection of radiation-induced biochemical alterations within cancer cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría Raman / Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría Raman / Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido