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Allopurinol hypersensitivity syndrome Raising awareness of an uncommon but potentially serious adverse event among kidney stone patients.
Alotaibi, Tariq; Bjazevic, Jennifer; Kim, Richard; Gryn, Steven; Sultan, Nabil; Dresser, George; Razvi, Hassan.
Afiliación
  • Alotaibi T; Division of Urology, Department of Surgery, Schulich School of Medicine and Dentistry, London, ON, Canada.
  • Bjazevic J; Division of Urology, Department of Surgery, Schulich School of Medicine and Dentistry, London, ON, Canada.
  • Kim R; Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, London, ON, Canada.
  • Gryn S; Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, London, ON, Canada.
  • Sultan N; Division of Nephrology, Department of Medicine, Schulich School of Medicine and Dentistry, London, ON, Canada.
  • Dresser G; Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, London, ON, Canada.
  • Razvi H; Division of Urology, Department of Surgery, Schulich School of Medicine and Dentistry, London, ON, Canada.
Can Urol Assoc J ; 18(5): E167-E172, 2024 May.
Article en En | MEDLINE | ID: mdl-38319608
ABSTRACT
Allopurinol is a commonly prescribed agent in the urologic population for the prevention of urinary stones. Although generally well-tolerated, several serious potential side effects can occur with its use. Allopurinol hypersensitivity syndrome (AHS), in particular, is a relatively rare but potentially life-threatening complication. With the observed increase in urinary stone disease, especially those of uric acid composition, it is likely that the use of allopurinol will increase. Urologists play an important role in the assessment and medical management of patients with urinary stones, thus a greater awareness of the potential adverse events associated with allopurinol use, especially AHS, is important, as well as strategies that can minimize such risks. Herein, we review the potential adverse effects of allopurinol. In addition, the results of a comprehensive review of the current literature on AHS will be presented, highlighting those patients at highest risk, reviewing the genetic susceptibility testing currently available, and providing guidance on best practices when allopurinol therapy is being considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Can Urol Assoc J Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Can Urol Assoc J Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Canadá