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Efficacy of SGLT2 inhibitors in IgA nephropathy associated with alcoholic liver cirrhosis accompanied by nephrotic syndrome: a case report.
Yoshimura, Yusuke; Ikuma, Daisuke; Mizuno, Hiroki; Kono, Kei; Kinowaki, Keiichi; Sugimoto, Hisashi; Kamido, Hisashi; Sawada, Yuichiro; Mizuta, Masato; Kurihara, Shigekazu; Oba, Yuki; Yamanouchi, Masayuki; Suwabe, Tatsuya; Ohashi, Kenichi; Ubara, Yoshifumi; Sawa, Naoki.
Afiliación
  • Yoshimura Y; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Ikuma D; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Mizuno H; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Kono K; Department of Pathology, Toranomon Hospital, Minato-ku, Tokyo, Japan.
  • Kinowaki K; Department of Pathology, Toranomon Hospital, Minato-ku, Tokyo, Japan.
  • Sugimoto H; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Kamido H; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Sawada Y; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Mizuta M; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Kurihara S; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Oba Y; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Yamanouchi M; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Suwabe T; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Ohashi K; Department of Pathology, Toranomon Hospital, Minato-ku, Tokyo, Japan.
  • Ubara Y; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
  • Sawa N; Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa, Japan.
Front Nephrol ; 3: 1331757, 2023.
Article en En | MEDLINE | ID: mdl-38318200
ABSTRACT
We present a 51-year-old male patient with a history of Child-Pugh Grade B alcoholic liver cirrhosis (ALC) who developed renal impairment (serum creatinine of 2.00 mg/dL) and nephrotic syndrome (a urinary protein level of 4.35 g/gCr). The patient was diagnosed with immunoglobulin A nephropathy (IgAN) associated with ALC based on findings from comprehensive evaluations, including markedly elevated serum IgA levels (883.7 mg/dL), a kidney biopsy revealing significant IgA deposition in the para-mesangial area, and a liver diagnosis showing long-standing advanced ALC. Our treatment approach involved initiating dapagliflozin therapy, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, alongside strict alcohol abstinence. Remarkably, the patient demonstrated a dramatic reduction in proteinuria within one week of dapagliflozin administration. No hypoglycemic events were observed. This case adds valuable clinical insights into the potential therapeutic role of SGLT2 inhibitors in IgAN associated with ALC. Specifically, in cases where conventional steroid therapies may be contraindicated due to coexisting comorbidities such as diabetes or obesity, dapagliflozin emerges as a potentially efficacious alternative. Further investigations are warranted to validate these preliminary observations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Nephrol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Nephrol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza