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Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma.
Prakash, Ajay; Rubin, Nathan; Staley, Christopher; Onyeaghala, Guillaume; Wen, Ya-Feng; Shaukat, Aasma; Milne, Ginger; Straka, Robert J; Church, Timothy R; Prizment, Anna.
Afiliación
  • Prakash A; Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA. praka086@umn.edu.
  • Rubin N; Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Staley C; Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Onyeaghala G; Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
  • Wen YF; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
  • Shaukat A; NYU Langone Medical Center, New York, NY, USA.
  • Milne G; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Straka RJ; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
  • Church TR; Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Prizment A; Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA.
Sci Rep ; 14(1): 2988, 2024 02 05.
Article en En | MEDLINE | ID: mdl-38316805
ABSTRACT
Ginger has been associated with a decreased incidence of colorectal cancer (CRC) through reduction in inflammatory pathways and inhibition of tumor growth. Recent pre-clinical models have implicated changes in the gut microbiome as a possible mediator of the ginger effect on CRC. We hypothesized that, in adults previously diagnosed with a colorectal adenoma, ginger supplementation would alter the fecal microbiome in the direction consistent with its CRC-inhibitory effect. Sixty-eight adults were randomized to take either ginger or placebo daily for 6 weeks, with a 6-week washout and longitudinal stool collection throughout. We performed 16S rRNA sequencing and evaluated changes in overall microbial diversity and the relative abundances of pre-specified CRC-associated taxa using mixed-effects logistic regression. Ginger supplementation showed no significant effect on microbial community structure through alpha or beta diversity. Of 10 pre-specified CRC-associated taxa, there were significant decreases in the relative abundances of the genera Akkermansia (p < 0.001), Bacteroides (p = 0.018), and Ruminococcus (p = 0.013) after 6-week treatment with ginger compared to placebo. Ginger supplementation led to decreased abundances of Akkermansia and Bacteroides, which suggests that ginger may have an inhibitory effect on CRC-associated taxa. Overall, ginger supplementation appears to have a limited effect on gut microbiome in patients with colorectal adenomas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Zingiber officinale / Microbiota Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Zingiber officinale / Microbiota Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido