Your browser doesn't support javascript.
loading
Accelerated Lung Function Decline and Mucus-Microbe Evolution in Chronic Obstructive Pulmonary Disease.
Meldrum, Oliver W; Donaldson, Gavin C; Narayana, Jayanth Kumar; Xaverius Ivan, Fransiskus; Jaggi, Tavleen K; Mac Aogáin, Micheál; Finney, Lydia J; Allinson, James P; Wedzicha, Jadwiga A; Chotirmall, Sanjay H.
Afiliación
  • Meldrum OW; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Donaldson GC; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Narayana JK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Xaverius Ivan F; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Jaggi TK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Mac Aogáin M; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Finney LJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Allinson JP; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Wedzicha JA; Royal Brompton Hospital, London, United Kingdom; and.
  • Chotirmall SH; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Am J Respir Crit Care Med ; 210(3): 298-310, 2024 08 01.
Article en En | MEDLINE | ID: mdl-38315959
ABSTRACT
Rationale Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated lung function decline relates to mucus properties and the microbiome in COPD.

Objectives:

Longitudinal assessment of mucus and microbiome changes accompanying accelerated lung function decline in patients COPD.

Methods:

This was a prospective, longitudinal assessment of the London COPD cohort exhibiting the greatest FEV1 decline (n = 30; accelerated decline; 156 ml/yr FEV1 loss) and with no FEV1 decline (n = 28; nondecline; 49 ml/yr FEV1 gain) over time. Lung microbiomes from paired sputum (total 116 specimens) were assessed by shotgun metagenomics and corresponding mucus profiles evaluated for biochemical and biophysical properties. Measurements and Main

Results:

Biochemical and biophysical mucus properties are significantly altered in the accelerated decline group. Unsupervised principal component analysis showed clear separation, with mucus biochemistry associated with accelerated decline, whereas biophysical mucus characteristics contributed to interindividual variability. When mucus and microbes are considered together, an accelerated decline mucus-microbiome association emerges, characterized by increased mucin (MUC5AC [mucin 5AC] and MUC5B [mucin 5B]) concentration and the presence of Achromobacter and Klebsiella. As COPD progresses, mucus-microbiome shifts occur, initially characterized by low mucin concentration and transition from viscous to elastic dominance accompanied by the commensals Veillonella, Gemella, Rothia, and Prevotella (Global Initiative for Chronic Obstructive Lung Disease [GOLD] A and B) before transition to increased mucus viscosity, mucins, and DNA concentration together with the emergence of pathogenic microorganisms including Haemophilus, Moraxella, and Pseudomonas (GOLD E).

Conclusions:

Mucus-microbiome associations evolve over time with accelerated lung function decline, symptom progression, and exacerbations affording fresh therapeutic opportunities for early intervention.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esputo / Enfermedad Pulmonar Obstructiva Crónica / Microbiota / Moco Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esputo / Enfermedad Pulmonar Obstructiva Crónica / Microbiota / Moco Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos