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Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti-PD-1 Therapy.
Szóstak, Natalia; Handschuh, Luiza; Samelak-Czajka, Anna; Tomela, Katarzyna; Pietrzak, Bernadeta; Schmidt, Marcin; Galus, Lukasz; Mackiewicz, Jacek; Mackiewicz, Andrzej; Kozlowski, Piotr; Philips, Anna.
Afiliación
  • Szóstak N; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Handschuh L; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Samelak-Czajka A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Tomela K; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Pietrzak B; Chair of Medical Biotechnology, Department of Cancer Immunology, Poznan University of Medical Sciences, Poznan, Poland.
  • Schmidt M; Department of Food Biotechnology and Microbiology, Poznan University of Life Sciences, Poznan, Poland.
  • Galus L; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
  • Mackiewicz J; Department of Food Biotechnology and Microbiology, Poznan University of Life Sciences, Poznan, Poland.
  • Mackiewicz A; Department of Medical and Experimental Oncology, Institute of Oncology, Poznan University of Medical Sciences, Poland.
  • Kozlowski P; Department of Medical and Experimental Oncology, Institute of Oncology, Poznan University of Medical Sciences, Poland.
  • Philips A; Chair of Medical Biotechnology, Department of Cancer Immunology, Poznan University of Medical Sciences, Poznan, Poland.
Cancer Immunol Res ; 12(4): 427-439, 2024 Apr 02.
Article en En | MEDLINE | ID: mdl-38315788
ABSTRACT
Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study, we found that melanoma patients exhibited a distinct gut mycobiota structure compared with healthy participants. Candida albicans, Candida dubliniensis, and Neurospora crassa were more abundant in samples from patients with melanoma, whereas Saccharomyces cerevisiae and Debaryomyces hansenii were less abundant. During anti-PD-1 treatment, the relative amount of Malassezia restricta and C. albicans increased. A higher level of Saccharomyces paradoxus was associated with a positive response to anti-PD-1 treatment, whereas a higher level of Tetrapisispora blattae was associated with a lack of clinical benefits. High levels of M. restricta and C. albicans, elevated serum lactate dehydrogenase, and being overweight were linked to increased risk of melanoma progression and poorer response to anti-PD-1 treatment. Thus, this study has revealed melanoma-associated mycobiome dysbiosis, characterized by altered fungal composition and fungi species associated with a higher risk of melanoma progression, identifying a role for the gut mycobiome in melanoma progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Micobioma / Melanoma Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Immunol Res Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Micobioma / Melanoma Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Immunol Res Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos