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Effect of Sarcopenia on Swallowing in Patients With Head and Neck Cancer.
Colback, Angela A; Arkfeld, Daniel V; Evangelista, Lisa M; Paydar, Alireza; Raslan, Osama; Abouyared, Marianne; Cates, Daniel J.
Afiliación
  • Colback AA; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
  • Arkfeld DV; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
  • Evangelista LM; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
  • Paydar A; Department of Radiology, Division of Neuroradiology, University of California, Davis, Sacramento, California, USA.
  • Raslan O; Department of Radiology, Division of Neuroradiology, University of California, Davis, Sacramento, California, USA.
  • Abouyared M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
  • Cates DJ; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, California, USA.
Otolaryngol Head Neck Surg ; 170(5): 1331-1337, 2024 May.
Article en En | MEDLINE | ID: mdl-38314934
ABSTRACT

OBJECTIVE:

Sarcopenia, characterized by decreased skeletal muscle mass, is associated with poorer oncologic outcomes in head and neck cancer (HNC) patients. The effect of sarcopenia on swallowing following HNC treatment is unknown. This study aims to investigate the association of sarcopenia and swallowing dysfunction in patients treated for HNC. STUDY

DESIGN:

Retrospective cohort study.

SETTING:

Academic medical center.

METHODS:

Pretreatment sarcopenia was assessed using the skeletal muscle index calculated from cross-sectional imaging at the third cervical vertebra. Feeding tube dependence, patient-reported dysphagia, and swallowing safety were assessed before and after treatment with the Functional Oral Intake Scale, Eating Assessment Tool-10, and Penetration Aspiration Scale, respectively. The association between sarcopenia and swallowing dysfunction was evaluated.

RESULTS:

A total of 112 patients were included, 84 males (75%) and 28 females (25%). A total of 69 (61.6%) had sarcopenia prior to initiating HNC therapy. Sarcopenia was significantly associated with an elevated risk of patient-reported dysphagia (odds ratio [OR] = 2.71 [95% confidence interval, CI, 1.12-6.79]; P < .05). Multivariate logistic regression demonstrated that sarcopenia (OR = 15.18 [95% CI, 1.50-453.53]; P < .05) is an independent predictor for aspiration following treatment for HNC.

CONCLUSION:

Patients with pretreatment sarcopenia had higher rates of dysphagia before treatment and were more likely to develop aspiration after completion of HNC therapy. Sarcopenia is readily measured using cross-sectional imaging and may be useful for identifying patients at risk of swallowing dysfunction and those most likely to benefit from prehabilitation efforts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Deglución / Sarcopenia / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Otolaryngol Head Neck Surg Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Deglución / Sarcopenia / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Otolaryngol Head Neck Surg Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido