Your browser doesn't support javascript.
loading
Associations Between Family History of Alcohol and/or Substance Use Problems and Frontal Cortical Development From 9 to 13 Years of Age: A Longitudinal Analysis of the ABCD Study.
Gonçalves, Priscila Dib; Martins, Silvia S; Gebru, Nioud Mulugeta; Ryan-Pettes, Stacy R; Allgaier, Nicholas; Potter, Alexandra; Thompson, Wesley K; Johnson, Micah E; Garavan, Hugh; Talati, Ardesheer; Albaugh, Matthew D.
Afiliación
  • Gonçalves PD; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.
  • Martins SS; New York State Psychiatric Institute and Department of Psychiatry, Columbia University, New York, New York.
  • Gebru NM; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.
  • Ryan-Pettes SR; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island.
  • Allgaier N; Department of Psychology and Neuroscience Baylor University, Waco, Texas.
  • Potter A; Department of Psychiatry, University of Vermont, Burlington, Vermont.
  • Thompson WK; Department of Psychiatry, University of Vermont, Burlington, Vermont.
  • Johnson ME; Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, Oklahoma.
  • Garavan H; Department of Mental Health Law and Policy, College of Behavioral and Community Sciences, University of South Florida, Tampa, Florida.
  • Talati A; Department of Psychiatry, University of Vermont, Burlington, Vermont.
  • Albaugh MD; New York State Psychiatric Institute and Department of Psychiatry, Columbia University, New York, New York.
Biol Psychiatry Glob Open Sci ; 4(2): 100284, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38312852
ABSTRACT

Background:

Previous investigations that have examined associations between family history (FH) of alcohol/substance use and adolescent brain development have been primarily cross-sectional. Here, leveraging a large population-based sample of youths, we characterized frontal cortical trajectories among 9- to 13-year-olds with (FH+) versus without (FH-) an FH and examined sex as a potential moderator.

Methods:

We used data from 9710 participants in the Adolescent Brain Cognitive Development (ABCD) Study (release 4.0). FH+ was defined as having ≥1 biological parents and/or ≥2 biological grandparents with a history of alcohol/substance use problems (n = 2433). Our primary outcome was frontal cortical structural measures obtained at baseline (ages 9-11) and year 2 follow-up (ages 11-13). We used linear mixed-effects models to examine the extent to which FH status qualified frontal cortical development over the age span studied. Finally, we ran additional interactions with sex to test whether observed associations between FH and cortical development differed significantly between sexes.

Results:

For FH+ (vs. FH-) youths, we observed increased cortical thinning from 9 to 13 years across the frontal cortex as a whole. When we probed for sex differences, we observed significant declines in frontal cortical thickness among boys but not girls from ages 9 to 13 years. No associations were observed between FH and frontal cortical surface area or volume.

Conclusions:

Having a FH+ is associated with more rapid thinning of the frontal cortex across ages 9 to 13, with this effect driven primarily by male participants. Future studies will need to test whether the observed pattern of accelerated thinning predicts future substance use outcomes.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biol Psychiatry Glob Open Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biol Psychiatry Glob Open Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos