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Chronic lactate exposure promotes cardiomyocyte cytoskeleton remodelling.
Luti, Simone; Militello, Rosamaria; Pinto, Gabriella; Illiano, Anna; Marzocchini, Riccardo; Santi, Alice; Becatti, Matteo; Amoresano, Angela; Gamberi, Tania; Pellegrino, Alessio; Modesti, Alessandra; Modesti, Pietro Amedeo.
Afiliación
  • Luti S; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Militello R; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Pinto G; Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
  • Illiano A; Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
  • Marzocchini R; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Santi A; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Becatti M; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Amoresano A; Department of Chemical Sciences, University of Naples Federico II, Naples, Italy.
  • Gamberi T; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Pellegrino A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Modesti A; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Modesti PA; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Heliyon ; 10(2): e24719, 2024 Jan 30.
Article en En | MEDLINE | ID: mdl-38312589
ABSTRACT
We investigated the effect of growing on lactate instead of glucose in human cardiomyocyte assessing their viability, cell cycle activity, oxidative stress and metabolism by a proteomic and metabolomic approach. In previous studies performed on elite players, we found that adaptation to exercise is characterized by a chronic high plasma level of lactate. Lactate is considered not only an energy source but also a signalling molecule and is referred as "lactormone"; heart is one of the major recipients of exogenous lactate. With this in mind, we used a cardiac cell line AC16 to characterize the lactate metabolic profile and investigate the metabolic flexibility of the heart. Interestingly, our data indicated that cardiomyocytes grown on lactate (72 h) show change in several proteins and metabolites linked to cell hypertrophy and cytoskeleton remodelling. The obtained results could help to understand the effect of this metabolite on heart of high-performance athletes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido