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More Similar than Different: Memory, Executive Functions, Cortical Thickness, and Glucose Metabolism in Biomarker-Positive Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia.
Keith, Cierra M; Haut, Marc W; D'Haese, Pierre-François; Mehta, Rashi I; Vieira Ligo Teixeira, Camila; Coleman, Michelle M; Miller, Mark; Ward, Melanie; Navia, R Osvaldo; Marano, Gary; Wang, Xiaofei; McCuddy, William T; Lindberg, Katharine; Wilhelmsen, Kirk C.
Afiliación
  • Keith CM; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA.
  • Haut MW; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
  • D'Haese PF; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA.
  • Mehta RI; Department of Neurology, West Virginia University, Morgantown, WV, USA.
  • Vieira Ligo Teixeira C; Department of Radiology, West Virginia University, Morgantown, WV, USA.
  • Coleman MM; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
  • Miller M; Department of Neuroradiology, West Virginia University, Morgantown, WV, USA.
  • Ward M; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
  • Navia RO; Department of Neuroradiology, West Virginia University, Morgantown, WV, USA.
  • Marano G; Department of Radiology, West Virginia University, Morgantown, WV, USA.
  • Wang X; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
  • McCuddy WT; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
  • Lindberg K; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
  • Wilhelmsen KC; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA.
J Alzheimers Dis Rep ; 8(1): 57-73, 2024.
Article en En | MEDLINE | ID: mdl-38312533
ABSTRACT

Background:

Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are typically associated with very different clinical and neuroanatomical presentations; however, there is increasing recognition of similarities.

Objective:

To examine memory and executive functions, as well as cortical thickness, and glucose metabolism in AD and bvFTD signature brain regions.

Methods:

We compared differences in a group of biomarker-defined participants with Alzheimer's disease and a group of clinically diagnosed participants with bvFTD. These groups were also contrasted with healthy controls (HC).

Results:

As expected, memory functions were generally more impaired in AD, followed by bvFTD, and both clinical groups performed more poorly than the HC group. Executive function measures were similar in AD compared to bvFTD for motor sequencing and go/no-go, but bvFTD had more difficulty with a set shifting task. Participants with AD showed thinner cortex and lower glucose metabolism in the angular gyrus compared to bvFTD. Participants with bvFTD had thinner cortex in the insula and temporal pole relative to AD and healthy controls, but otherwise the two clinical groups were similar for other frontal and temporal signature regions.

Conclusions:

Overall, the results of this study highlight more similarities than differences between AD and bvFTD in terms of cognitive functions, cortical thickness, and glucose metabolism. Further research is needed to better understand the mechanisms mediating this overlap and how these relationships evolve longitudinally.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Alzheimers Dis Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Alzheimers Dis Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos