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Recurrent MTOR Mutations in Renal Cell Carcinoma With Fibromyomatous Stroma: A Report of 2 Tumors.
Palathingal Bava, Ejas; Gupta, Nilesh; Alruwaii, Fatimah I; Nelson, Ryan; Al-Obaidy, Khaleel I.
Afiliación
  • Palathingal Bava E; Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA.
  • Gupta N; Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA.
  • Alruwaii FI; Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
  • Nelson R; Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA.
  • Al-Obaidy KI; Department of Urology, Henry Ford Health, Detroit, MI, USA.
Int J Surg Pathol ; 32(7): 1409-1414, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38311893
ABSTRACT
Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with MTOR mutations occurring in 62- and 72-year-old women and review the literature to support its recognition as a distinct entity, focusing on the characteristic morphology, immunohistochemical staining patterns as well as genetic alterations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Serina-Treonina Quinasas TOR / Neoplasias Renales / Mutación Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Surg Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Serina-Treonina Quinasas TOR / Neoplasias Renales / Mutación Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Surg Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos