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Precise Design of TiO2@CoOx Heterostructure via Atomic Layer Deposition for Synergistic Sono-Chemodynamic Oncotherapy.
Liu, Wen; Shao, Runrun; Guo, Lingyun; Man, Jianliang; Zhang, Chengwu; Li, Lihong; Wang, Haojiang; Wang, Bin; Guo, Lixia; Ma, Sufang; Zhang, Bin; Diao, Haipeng; Qin, Yong; Yan, Lili.
Afiliación
  • Liu W; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Shao R; Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, 030001, P. R. China.
  • Guo L; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Man J; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Zhang C; Pharmacy College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Li L; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Wang H; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Wang B; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Guo L; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Ma S; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Zhang B; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Diao H; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
  • Qin Y; State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, 030001, P. R. China.
  • Yan L; Basic Medical College, Shanxi Medical University, Taiyuan, 030001, P. R. China.
Adv Sci (Weinh) ; 11(14): e2304046, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38311581
ABSTRACT
Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill tumor cells by producing cytotoxic reactive oxygen species (ROS) with ultrasound-triggered sonosensitizers. N-type inorganic semiconductor TiO2 has low ROS quantum yields under ultrasound irradiation and inadequate anti-tumor activity. Herein, by using atomic layer deposition (ALD) to create a heterojunction between porous TiO2 and CoOx, the sonodynamic therapy efficiency of TiO2 can be improved. Compared to conventional techniques, the high controllability of ALD allows for the delicate loading of CoOx nanoparticles into TiO2 pores, resulting in the precise tuning of the interfaces and energy band structures and ultimately optimal SDT properties. In addition, CoOx exhibits a cascade of H2O2→O2→·O2 - in response to the tumor microenvironment, which not only mitigates hypoxia during the SDT process, but also contributes to the effect of chemodynamic therapy (CDT). Correspondingly, the synergistic CDT/SDT treatment is successful in inhibiting tumor growth. Thus, ALD provides new avenues for catalytic tumor therapy and other pharmaceutical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Peróxido de Hidrógeno Límite: Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Peróxido de Hidrógeno Límite: Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2024 Tipo del documento: Article Pais de publicación: Alemania