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The effects of orlistat on oxidative stress, recognition memory, spatial memory and hippocampal tissue in experimentally induced obesity in rats.
Yigit, Ayse Arzu; Kilinc, Sevtap; Olcuoglu, Rukiye; Arnous, Elif Azra.
Afiliación
  • Yigit AA; Department of Physiology, Faculty of Medicine, Baskent University, Ankara 06790, Türkiye. Electronic address: aarzuyigit@baskent.edu.tr.
  • Kilinc S; Department of Physiology, Faculty of Medicine, Baskent University, Ankara 06790, Türkiye.
  • Olcuoglu R; Department of Physiology, Faculty of Medicine, Baskent University, Ankara 06790, Türkiye.
  • Arnous EA; Department of Physiology, Faculty of Medicine, Baskent University, Ankara 06790, Türkiye.
Behav Brain Res ; 462: 114894, 2024 03 28.
Article en En | MEDLINE | ID: mdl-38311071
ABSTRACT
This study investigates the impact of orlistat on oxidative stress, spatial memory, recognition memory, and hippocampal tissue in obese rats. The study groups were divided into control, high fat diet-induced obese (HFDIO), HFDIO+orlistat (HFDIO+ORL) groups, each consisting of 8 animals. While control fed with standart diet, HFDIO and HFDIO+ORL fed with high-fat diets for 8 weeks to induce obesity. Then, ORL treated 10 mg/kg for 7 weeks, while control and HFDIO get water. At 16th week, novel object recognition (NOR) and Morris water maze (MWM) tests were performed. TNF-alpha, IL-1beta levels in hippocampal tissue, and total/native thiol/disulphide levels in serum were measured. TNF-alpha level of HFDIO was higher than control, while lower in HFDIO+ORL compared to HFDIO as like IL-1beta level. On the contrary, serum total thiol level was lower in HFDIO than control and higher in HFDIO+ORL compared to the HFDIO, while disulphide level was opposite of the total thiol levels. While recognition index was higher in HFDIO+ORL, in MWM, latency of finding platform in HFDIO was higher than control and latency of HFDIO+ORL was very similar to control in 2-4 days. The HFDIO group demonstrated decrease in time spent in platform zone compared to control, whereas time spent of the HFDIO+ORL was higher than HFDIO. Our study demonstrates that orlistat administration exerts beneficial effects on oxidative stress, spatial memory, recognition memory, and hippocampal tissue in obese rats. It shows that orlistat may have potential therapeutic implications for obesity-related cognitive impairments and hippocampal dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor de Necrosis Tumoral alfa / Memoria Espacial Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor de Necrosis Tumoral alfa / Memoria Espacial Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos