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An integrating strategy for systematic profiling of Chinese patent drug's chemicalome and associated metabolome: Huanghou antidiarrhea dropping pills as a case study.
Li, Li; Wang, Xuguang; Ma, Ruiting; Hou, Mingxing.
Afiliación
  • Li L; Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210000, China; The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
  • Wang X; The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
  • Ma R; The Academy of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210097, China; The Inner Mongolia Mental Health Center, Hohhot 010010, China. Electronic address: maruiting0623@126.com.
  • Hou M; Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210000, China; The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China. Electronic address: houmingxingfy@126.com.
J Chromatogr B Analyt Technol Biomed Life Sci ; 1234: 124029, 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38310833
ABSTRACT
Huanghou antidiarrhea dropping pills (HADP) is an efficient Chinese patent drug that is clinically used to treat diarrhea. However, its functional materials remain unclear due to the characteristics of traditional Chinese medicine, which is a multi-component and multi-target complex system. In this study, we investigated the intrinsic chemical components and combined with in vivo metabolism to reveal the functional material basis of HADP. Spectral behavior (accurate molecular weight and secondary fragmentation) and chromatographic behavior (retention time) were key criterions that throughout the whole research of components identification, prototypes screening, and tissue distribution. Mass defect filter (MDF), characteristic product ion filter (PIF), and neutral loss filter (NLF) were other three criterions for metabolites searching. Consequently, a total of 102 components in HADP, including alkaloids, lignans, lactones, gingerols, and alkaloid complexes were identified or tentatively characterized. About 39 metabolites that related to 37 prototypes were calculated and matched in bio-samples. Among them, 14 prototypes and 18 metabolites were detected distribution in colon, liver, heart, spleen, lung or kidney. This study provides a systematic investigation into the metabolism of HADP and offers effective analytical strategies for the characterization of compounds and metabolites in Chinese patent drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Metaboloma Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Metaboloma Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos