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Association of Long COVID with mental health disorders: a retrospective cohort study using real-world data from the USA.
Zhang, Yue; Chinchilli, Vernon M; Ssentongo, Paddy; Ba, Djibril M.
Afiliación
  • Zhang Y; Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA ymz5503@psu.edu.
  • Chinchilli VM; Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Ssentongo P; Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Ba DM; Department of Medicine, Penn State Health Medical Center, Hershey, PA, USA.
BMJ Open ; 14(2): e079267, 2024 02 03.
Article en En | MEDLINE | ID: mdl-38309763
ABSTRACT

OBJECTIVES:

Mental health disorders (MHD) rank third for US adult hospitalisations. Given the substantial prevalence of 'Long COVID' in SARS-CoV-2 survivors, this study aims to assess its association with increased MHD risk using extensive real-world data.

DESIGN:

A retrospective cohort study with propensity score matching was conducted. We used the International Classification of Diseases, 10th Revision codes to identify individuals with Long COVID status and COVID-19 histories. Multivariable stratified Cox proportional hazards regression analysis was conducted to determine the association of Long COVID status with MHD.

SETTING:

Data were sourced from the TriNetX database, spanning records from 1 October 2021 to 16 April 2023.

PARTICIPANTS:

Two distinct cohorts were established one comprising individuals diagnosed with Long COVID and another comprising individuals with no history of Long COVID or COVID-19. At the start of the study, none of the participants had a recorded MHD. PRIMARY AND SECONDARY OUTCOME

MEASURES:

The main outcome of interest was a composite diagnosis of MHD. Secondary outcomes were individual mental health conditions.

RESULTS:

The study included 43 060 control participants without Long COVID and 4306 Long COVID participants, demonstrating well-balanced distribution across all covariates. After adjusting for 4 demographic factors and 10 comorbidities, Long COVID was associated with MHD (adjusted HR, aHR 2.60; 95% CI 2.37 to 2.85). In subgroup analysis, Long COVID was associated with major depression disorder (aHR 3.36; 95% CI 2.82 to 4.00) and generalised anxiety disorder (aHR 3.44; 95% CI 2.99 to 3.96).

CONCLUSIONS:

In this retrospective large real-world cohort study, Long COVID was associated with an increased risk of incident MHD. The MHD impact is significant considering the vast number of patients with Long COVID. Enhanced MHD screening among COVID-19 survivors should be a priority.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: BMJ Open Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: BMJ Open Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido