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Evaluating a novel accelerated free-breathing late gadolinium enhancement imaging sequence for assessment of myocardial injury.
Bhatt, Nitish; Orbach, Ady; Biswas, Labonny; Strauss, Bradley H; Connelly, Kim; Ghugre, Nilesh R; Wright, Graham A; Roifman, Idan.
Afiliación
  • Bhatt N; Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  • Orbach A; Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Biswas L; Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Strauss BH; Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Connelly K; Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada.
  • Ghugre NR; Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Wright GA; Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Roifman I; Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address: idan.roifman@sunnybrook.ca.
Magn Reson Imaging ; 108: 40-46, 2024 May.
Article en En | MEDLINE | ID: mdl-38309379
ABSTRACT

INTRODUCTION:

Cardiac magnetic resonance imaging (MRI), including late gadolinium enhancement (LGE), plays an important role in the diagnosis and prognostication of ischemic and non-ischemic myocardial injury. Conventional LGE sequences require patients to perform multiple breath-holds and require long acquisition times. In this study, we compare image quality and assessment of myocardial LGE using an accelerated free-breathing sequence to the conventional standard-of-care sequence.

METHODS:

In this prospective cohort study, a total of 41 patients post Coronavirus 2019 (COVID-19) infection were included. Studies were performed on a 1.5 Tesla scanner with LGE imaging acquired using a conventional inversion recovery rapid gradient echo (conventional LGE) sequence followed by the novel accelerated free-breathing (FB-LGE) sequence. Image quality was visually scored (ordinal scale from 1 to 5) and compared between conventional and free-breathing sequences using the Wilcoxon rank sum test. Presence of per-segment LGE was identified according to the American Heart Association 16-segment myocardial model and compared across both conventional LGE and FB-LGE sequences using a two-sided chi-square test. The perpatient LGE extent was also evaluated using both sequences and compared using the Wilcoxon rank sum test. Interobserver variability in detection of per-segment LGE and per-patient LGE extent was evaluated using Cohen's kappa statistic and interclass correlation (ICC), respectively.

RESULTS:

The mean acquisition time for the FB-LGE sequence was 17 s compared to 413 s for the conventional LGE sequence (P < 0.001). Assessment of image quality was similar between both sequences (P = 0.19). There were no statistically significant differences in LGE assessed using the FB-LGE versus conventional LGE on a per-segment (P = 0.42) and per-patient (P = 0.06) basis. Interobserver variability in LGE assessment for FB-LGE was good for per-segment (= 0.71) and per-patient extent (ICC = 0.92) analyses.

CONCLUSIONS:

The accelerated FB-LGE sequence performed comparably to the conventional standard-of-care LGE sequence in a cohort of patients post COVID-19 infection in a fraction of the time and without the need for breath-holding. Such a sequence could impact clinical practice by increasing cardiac MRI throughput and accessibility for frail or acutely ill patients unable to perform breath-holding.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medios de Contraste / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Magn Reson Imaging Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medios de Contraste / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Magn Reson Imaging Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos