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Pre- and Postoperative Antioxidant Use, Aryl Hydrocarbon Receptor (AhR) Activation and Clinical Outcome in Different Treatment Groups of Breast Cancer Patients.
Nilsson, Linn; Khazaei, Somayeh; Tryggvadottir, Helga; Björner, Sofie; Bressan, Alessandra; Jirström, Karin; Adrian, Gabriel; Falck, Anna-Karin; Borgquist, Signe; Isaksson, Karolin; Jernström, Helena.
Afiliación
  • Nilsson L; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden; Department of Medical Physics and Engineering, Växjö Central Hospital and Department of Research and Development, Region Kronoberg, Växjö, Sweden.
  • Khazaei S; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden.
  • Tryggvadottir H; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Björner S; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden.
  • Bressan A; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden.
  • Jirström K; Department of Clinical Sciences, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden.
  • Adrian G; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden; Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Falck AK; Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden.
  • Borgquist S; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden; Department of Oncology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Isaksson K; Department of Clinical Sciences, Division of Surgery, Lund University, Lund, Sweden; Department of Surgery, Kristianstad Hospital, Kristianstad, Sweden.
  • Jernström H; Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden. Electronic address: helena.jernstrom@med.lu.se.
Clin Breast Cancer ; 24(3): e152-e166.e9, 2024 04.
Article en En | MEDLINE | ID: mdl-38307727
ABSTRACT

BACKGROUND:

Cancer patients often use antioxidants that may interact with adjuvant treatments. The purpose was to investigate pre- and postoperative antioxidant use in relation to clinicopathological characteristics and prognosis in different breast cancer treatment groups. METHODS AND PATIENTS Pre- and postoperative antioxidant (vitamin A, C, E, carotenoids, or Q10) or multivitamin use was self-reported by patients from Lund (n = 1855) and Helsingborg (n=478), Sweden. Patients were followed for up to 15 years. Clinical data were obtained from patient charts. The aryl hydrocarbon receptor (AhR) was evaluated in tumor tissue arrays from 915 patients from Lund and with Western blot in MCF-7 and MDA-MB-231 cells.

RESULTS:

About 10% of patients used antioxidants. Nuclear AhR (AhRnuc) positivity was twice as common in preoperative antioxidant users compared to non-users. In mechanistic studies vitamin C increased AhR levels and its downstream target CYP1B1, indicating AhR activation. There were significant interactions between tumor AhRnuc status and preoperative antioxidant use in relation to clinical outcome. In all patients, antioxidant use (other than multivitamins) at both visits was associated with poorer prognosis, while use only at the follow-up visit was associated with better prognosis, compared with no use at either visit.

CONCLUSION:

The clinical impact of antioxidants depended on antioxidant type, timing of use, and tumor AhR activation. Antioxidants may influence clinical outcome by activation of the master regulator AhR in addition to interference with free radicals. Further studies are needed to identify breast patients that might improve or worsen their prognosis when using antioxidants postoperatively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Clin Breast Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Clin Breast Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos