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Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes.
Putira Sacuena, Eliene Rodrigues; Lima, Carlos Neandro Cordeiro; Abreu, Isabella Nogueira; da Silva, Lucas Matheus Cavalcante; Belleza, Lilian Karen Goes; Lemes, Renan Barbosa; de Araújo, Gilderlânio Santana; da Silva, Hilton Pereira; Vallinoto, Antônio Carlos Rosário; Guerreiro, João Farias.
Afiliación
  • Putira Sacuena ER; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil; Laboratory of Bioanthropological Studies in Health and Environment, Institute of Philosophy and Human Sciences, Federal University of Pará, Brazil.
  • Lima CNC; Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil.
  • Abreu IN; Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil.
  • da Silva LMC; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
  • Belleza LKG; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
  • Lemes RB; Laboratory of Human Population Genomics, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
  • de Araújo GS; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
  • da Silva HP; Laboratory of Bioanthropological Studies in Health and Environment, Institute of Philosophy and Human Sciences, Federal University of Pará, Brazil.
  • Vallinoto ACR; Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil.
  • Guerreiro JF; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil. Electronic address: joao.guerreiro53@gmail.com.
Infect Genet Evol ; 118: 105564, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38307396
ABSTRACT
This pilot study aimed to investigate genetic factors that may have contributed to the milder clinical outcomes of COVID-19 in Brazilian indigenous populations. 263 Indigenous from the Araweté, Kararaô, Parakanã, Xikrin do Bacajá, Kayapó and Munduruku peoples were analyzed, 55.2% women, ages ranging from 10 to 95 years (average 49.5 ± 20.7). Variants in genes involved in the entry of SARS-CoV-2 into the host cell (ACE1 rs1799752 I/D, ACE2 rs2285666 C/T, ACE2 rs73635825 A/G and TMPRSS2 rs123297605 C/T), were genotyped in indigenous peoples from the Brazilian Amazon, treated during the SARS-CoV-2 pandemic between 2020 and 2021. The distribution of genotypes did not show any association with the presence or absence of IgG antibodies. Additionally, the influence of genetic variations on the severity of the disease was not examined extensively because a significant number of indigenous individuals experienced the disease with either mild symptoms or no symptoms. It is worth noting that the frequencies of risk alleles were found to be lower in Indigenous populations compared to both continental populations and Brazilians. Indigenous Brazilian Amazon people exhibited an ethnic-specific genetic profile that may be associated with a milder disease, which could explain the unexpected response they demonstrated to COVID-19, being less impacted than Brazilians.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Peptidil-Dipeptidasa A / COVID-19 Límite: Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Peptidil-Dipeptidasa A / COVID-19 Límite: Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos