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Intraoperative Music to Promote Patient Outcome (IMPROMPTU): A Double-Blind Randomized Controlled Trial.
Fu, Victor X; Lagarde, Sjoerd M; Favoccia, Christian T; Heisterkamp, Joos; van Oers, Annemarie E; Coene, Peter-Paul L O; Koopman, Josèph S H A; van den Berg, Sjoerd A A; Dik, Willem A; Jeekel, Johannes; Wijnhoven, Bas P L.
Afiliación
  • Fu VX; Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: v.fu@erasmusmc.nl.
  • Lagarde SM; Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Favoccia CT; Department of Anesthesiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Heisterkamp J; Department of Surgery, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
  • van Oers AE; Department of Anesthesiology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
  • Coene PLO; Department of Surgery, Maasstad Hospital, Rotterdam, The Netherlands.
  • Koopman JSHA; Department of Anesthesiology, Maasstad Hospital, Rotterdam, The Netherlands.
  • van den Berg SAA; Department of Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Dik WA; Department of Immunology, Laboratory Medical Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Jeekel J; Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Wijnhoven BPL; Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
J Surg Res ; 296: 291-301, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38306934
ABSTRACT

INTRODUCTION:

Perioperative music can have beneficial effects on postoperative pain, anxiety, opioid requirement, and the physiological stress response to surgery. The aim was to assess the effects of intraoperative music during general anesthesia in patients undergoing surgery for esophagogastric cancer. MATERIALS AND

METHODS:

The IMPROMPTU study was a double-blind, placebo-controlled, randomized multicenter trial. Adult patients undergoing surgery for stage II-III esophagogastric cancer were eligible. Exclusion criteria were a hearing impairment, insufficient Dutch language knowledge, corticosteroids use, or objection to hearing unknown music. Patients wore active noise-cancelling headphones intraoperatively with preselected instrumental classical music (intervention) or no music (control). Computerized randomization with centralized allocation, stratified according to surgical procedure using variable block sizes, was employed. Primary endpoint was postoperative pain on the first postoperative day. Secondary endpoints were postoperative pain during the first postoperative week, postoperative opioid requirement, intraoperative medication requirement, the stress response to surgery, postoperative complication rate, length of stay, and mortality, with follow-up lasting 30 d.

RESULTS:

From November 2018 to September 2020, 145 patients were assessed and 83 randomized. Seventy patients (music n = 31, control n = 39) were analyzed. Median age was 70 [IQR 63-70], and 48 patients (69%) were male. Music did not reduce postoperative pain (numeric rating scale 1.8 (SD0.94) versus 2.0 (1.0), mean difference -0.28 [95% CI -0.76-0.19], P = 0.236). No statistically significant differences were seen in medication requirement, stress response, complication rate, or length of stay.

CONCLUSIONS:

Intraoperative, preselected, classical music during esophagogastric cancer surgery did not significantly improve postoperative outcome and recovery when compared to no music using noise-cancelling headphones.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Neoplasias Esofágicas / Música Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: J Surg Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Neoplasias Esofágicas / Música Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: J Surg Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos