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Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study.
Vestin, Erika; Boström, Gustaf; Olsson, Jan; Elgh, Fredrik; Lind, Lars; Kilander, Lena; Lövheim, Hugo; Weidung, Bodil.
Afiliación
  • Vestin E; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
  • Boström G; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
  • Olsson J; Centre for Clinical Research, Västmanland and County Hospital, Uppsala University, Västerås, Sweden.
  • Elgh F; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Lind L; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Kilander L; Department of Medical Sciences, Acute and Internal Medicine, Uppsala University, Uppsala, Sweden.
  • Lövheim H; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
  • Weidung B; Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
J Alzheimers Dis ; 97(4): 1841-1850, 2024.
Article en En | MEDLINE | ID: mdl-38306033
ABSTRACT

Background:

Evidence indicates that herpes simplex virus (HSV) participates in the pathogenesis of Alzheimer's disease (AD).

Objective:

We investigated AD and dementia risks according to the presence of herpesvirus antibodies in relation to anti-herpesvirus treatment and potential APOE ɛ4 carriership interaction.

Methods:

This study was conducted with 1002 dementia-free 70-year-olds living in Sweden in 2001-2005 who were followed for 15 years. Serum samples were analyzed to detect anti-HSV and anti-HSV-1 immunoglobulin (Ig) G, anti-cytomegalovirus (CMV) IgG, anti-HSV IgM, and anti-HSV and anti-CMV IgG levels. Diagnoses and drug prescriptions were collected from medical records. Cox proportional-hazards regression models were applied.

Results:

Cumulative AD and all-cause dementia incidences were 4% and 7%, respectively. Eighty-two percent of participants were anti-HSV IgG carriers, of whom 6% received anti-herpesvirus treatment. Anti-HSV IgG was associated with a more than doubled dementia risk (fully adjusted hazard ratio = 2.26, p = 0.031). No significant association was found with AD, but the hazard ratio was of the same magnitude as for dementia. Anti-HSV IgM and anti-CMV IgG prevalence, anti-herpesvirus treatment, and anti-HSV and -CMV IgG levels were not associated with AD or dementia, nor were interactions between anti-HSV IgG and APOE ɛ4 or anti-CMV IgG. Similar results were obtained for HSV-1.

Conclusions:

HSV (but not CMV) infection may be indicative of doubled dementia risk. The low AD incidence in this cohort may have impaired the statistical power to detect associations with AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Herpesvirus Humano 1 / Infecciones por Citomegalovirus / Enfermedad de Alzheimer / Herpes Simple Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Herpesvirus Humano 1 / Infecciones por Citomegalovirus / Enfermedad de Alzheimer / Herpes Simple Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos