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Association of disease activity with depression and anxiety in systemic lupus erythematosus: A comparison of SLEDAI-2K and SLE-DAS.
Yang, Leilei; Gu, Bingjie; Wang, Xiaoqin; Ren, Qijie; Shen, Minning; Su, Dinglei.
Afiliación
  • Yang L; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing city, Jiangsu Province, China.
  • Gu B; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing city, Jiangsu Province, China.
  • Wang X; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing city, Jiangsu Province, China.
  • Ren Q; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing city, Jiangsu Province, China.
  • Shen M; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing city, Jiangsu Province, China.
  • Su D; Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing city, Jiangsu Province, China.
Rheumatology (Oxford) ; 2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38305645
ABSTRACT

OBJECTIVE:

To explore the association of disease activity, as evaluated by both the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) and the Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K), with depression and anxiety in patients with systemic lupus erythematosus (SLE).

METHODS:

A cross-sectional study was conducted among 85 Chinese patients with SLE. Disease activity was measured using SLEDAI-2K and SLE-DAS scoring systems. Depression and anxiety were assessed using Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale-7 (GAD-7), respectively. Multivariate logistic regression analysis was performed to evaluate the association of disease activity scores, as well as specific clinical and laboratory items, with depression and anxiety.

RESULTS:

There was a robust correlation between SLEDAI-2K and SLE-DAS scores in overall patients (Spearman's r = 0.764, 95% confidence interval (CI) 0.655-0.842; p< 0.001) and those with moderate-to-high disease activity (Spearman's r = 0.792, 95%CI 0.616-0.892; p< 0.0001). However, the correlation weakened for patients with mild disease activity or remission (Spearman's r = 0.450, 95%CI 0.188-0.652; p= 0.001). Multivariate logistic regression analysis did not show a significant correlation between SLEDAI-2K and SLE-DAS scores and depression/anxiety. The presence of mucosal ulcer/serositis significantly increased the risk of depression (OR = 4.472, 95%CI 1.035-19.328, p= 0.045) and anxiety (OR = 3.978, 95%CI 1.051-15.049, p= 0.042).

CONCLUSION:

The SLE-DAS scoring system demonstrated a comparable ability to assess disease activity in SLE compared with SLEDAI-2K. Though neither scoring system showed significant associations with depression and anxiety, the presence of mucosal ulcer/serositis markedly heightened the risk of both among SLE patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido