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Nonvariceal upper gastrointestinal bleeding in COVID-19 patients: insights from the National Inpatient Sample.
Jaan, Ali; Sarfraz, Zouina; Farooq, Umer; Gutman, Jason; McFarland, Joel E; Mahmood, Sultan; Dunnigan, Karin; Cryer, Byron; Okolo, Patrick.
Afiliación
  • Jaan A; Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA.
  • Sarfraz Z; Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan.
  • Farooq U; Department of Gastroenterology and Hepatology, Saint Louis University, St. Louis, MO, USA.
  • Gutman J; Department of Gastroenterology and Hepatology, Rochester General Hospital, Rochester, NY, USA.
  • McFarland JE; Department of Gastroenterology and Hepatology, Rochester General Hospital, Rochester, NY, USA.
  • Mahmood S; Department of Gastroenterology and Hepatology, University of Pittsburgh Medical Center Pittsburgh, PA, USA.
  • Dunnigan K; Department of Gastroenterology and Hepatology, Rochester General Hospital, Rochester, NY, USA.
  • Cryer B; Department of Gastroenterology and Hepatology, Baylor University Medical Center, Dallas, TX, USA.
  • Okolo P; Department of Gastroenterology and Hepatology, Rochester General Hospital, Rochester, NY, USA.
Scand J Gastroenterol ; 59(5): 615-622, 2024 May.
Article en En | MEDLINE | ID: mdl-38305194
ABSTRACT

BACKGROUND:

This retrospective study, conducted using the U.S. National Inpatient Sample (NIS), examines the outcomes and management of nonvariceal upper gastrointestinal bleeding (NVUGIB) in COVID-19 patients and identifies predictive factors to enhance patient prognosis.

METHODS:

We analyzed the 2020 U.S. NIS data involving adult patients (≥18 years) admitted with NVUGIB and categorized them based on the presence of COVID-19. Primary and secondary outcomes, NVUGIB-related procedures, and predictive factors were evaluated.

RESULTS:

Of 184,885 adult patients admitted with NVUGIB, 1.6% (2990) had COVID-19. Patients with NVUGIB and COVID-19 showed higher inpatient mortality, acute kidney injury, need for intensive care, and resource utilization metrics. Notably, there was a lower rate of early esophagogastroduodenoscopy (EGD). Multivariate logistic regression revealed conditions like peptic ulcer disease, mechanical ventilation, and alcohol abuse as significant positive predictors for NVUGIB in COVID-19 patients, whereas female gender and smoking were negative predictors.

CONCLUSION:

Our findings suggest that COVID-19 significantly increases the risk of mortality and complications in NVUGIB patients. The observed decrease in early EGD interventions, potentially contributing to higher mortality rates, calls for a review of treatment strategies. Further multicenter, prospective studies are needed to validate these results and improve patient care strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mortalidad Hospitalaria / COVID-19 / Hemorragia Gastrointestinal Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Scand J Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mortalidad Hospitalaria / COVID-19 / Hemorragia Gastrointestinal Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Scand J Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido