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Challenges in Emerging Vaccines and Future Promising Candidates against SARS-CoV-2 Variants.
Ghildiyal, Tanmay; Rai, Nishant; Mishra Rawat, Janhvi; Singh, Maargavi; Anand, Jigisha; Pant, Gaurav; Kumar, Gaurav; Shidiki, Amrullah.
Afiliación
  • Ghildiyal T; Department of Microbial Biotechnology, Panjab University, Chandigarh, India.
  • Rai N; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, India.
  • Mishra Rawat J; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, India.
  • Singh M; Department of Instrumentation and Control Engineering, Manipal Institute of Technology, Manipal, Karnataka, India.
  • Anand J; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, India.
  • Pant G; Department of Microbiology, Graphic Era Deemed to be University, Dehradun, India.
  • Kumar G; Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India.
  • Shidiki A; National Medical College and Teaching Hospital, Birgunj, Nepal.
J Immunol Res ; 2024: 9125398, 2024.
Article en En | MEDLINE | ID: mdl-38304142
ABSTRACT
Since the COVID-19 outbreak, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus has evolved into variants with varied infectivity. Vaccines developed against COVID-19 infection have boosted immunity, but there is still uncertainty on how long the immunity from natural infection or vaccination will last. The present study attempts to outline the present level of information about the contagiousness and spread of SARS-CoV-2 variants of interest and variants of concern (VOCs). The keywords like COVID-19 vaccine types, VOCs, universal vaccines, bivalent, and other relevant terms were searched in NCBI, Science Direct, and WHO databases to review the published literature. The review provides an integrative discussion on the current state of knowledge on the type of vaccines developed against SARS-CoV-2, the safety and efficacy of COVID-19 vaccines concerning the VOCs, and prospects of novel universal, chimeric, and bivalent mRNA vaccines efficacy to fend off existing variants and other emerging coronaviruses. Genomic variation can be quite significant, as seen by the notable differences in impact, transmission rate, morbidity, and death during several human coronavirus outbreaks. Therefore, understanding the amount and characteristics of coronavirus genetic diversity in historical and contemporary strains can help researchers get an edge over upcoming variants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Humans Idioma: En Revista: J Immunol Res Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Egipto
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Límite: Humans Idioma: En Revista: J Immunol Res Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Egipto