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Diagnostic accuracy of intraoperative frozen section for margin evaluation of oral cavity squamous cell carcinoma.
Ali, Javaria P; Mallick, Bakhtawar Allauddin; Rashid, Khushbakht; Malik, Umair Arshad; Hashmi, Atif Ali; Zia, Shamail; Irfan, Muhammad; Khan, Amir; Faridi, Naveen.
Afiliación
  • Ali JP; Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.
  • Mallick BA; Zainab Panjwani Memorial Hospital, Karachi, Pakistan.
  • Rashid K; Emergency Medicine, Al-Rayaz Hospital, Karachi, Pakistan.
  • Malik UA; Prime Cardiology of Nevada, Las Vegas, USA.
  • Hashmi AA; Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
  • Zia S; Department of Internal Medicine, Aga Khan University, Karachi, Pakistan.
  • Irfan M; Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan.
  • Khan A; Department of Pathology, Jinnah Sindh Medical University, Karachi, Pakistan.
  • Faridi N; Department of Biostatistics, Liaquat National Hospital and Medical College, Karachi, Pakistan.
BMC Res Notes ; 17(1): 43, 2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38303028
ABSTRACT

OBJECTIVES:

Intraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell carcinoma. We conducted this study to determine the diagnostic accuracy of frozen section in detecting margin status and the effect of tumor grade and stage on diagnostic accuracy.

RESULTS:

A total of 251 biopsy-proven cases of oral squamous cell carcinoma were included in this study. The tissue specimen resected during surgery was sent to the laboratory for frozen section evaluation. The frozen section results were then compared with the permanent section results to determine the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy. The mean age of the patients included in the study was 51.65 ± 10.03 years, with male predominance (55.4%). The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of frozen section were 88.81%, 94.84%, 95.20%, 88.10%, and 91.63%, respectively. We conclude that frozen section is a useful technique in determining the margin status intraoperatively in oral cancers, with high diagnostic accuracy. Moreover, certain clinical parameters such as age, gender, disease duration, and tumor stage and grade appear to affect the diagnostic accuracy of frozen section.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Res Notes Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Res Notes Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido