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The Addis Ababa Lions: Whole-Genome Sequencing of a Rare and Precious Population.
Barazandeh, Marjan; Kriti, Divya; Fickel, Jörns; Nislow, Corey.
Afiliación
  • Barazandeh M; Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Kriti D; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Fickel J; Institute for Biochemistry and Biology, University Potsdam, Potsdam, Germany.
  • Nislow C; Department of Evolutionary Genetics, Research Institute for Zoo and Wildlife Research (IZW), Berlin, Germany.
Genome Biol Evol ; 16(2)2024 02 01.
Article en En | MEDLINE | ID: mdl-38302110
ABSTRACT
Lions are widely known as charismatic predators that once roamed across the globe, but their populations have been greatly affected by environmental factors and human activities over the last 150 yr. Of particular interest is the Addis Ababa lion population, which has been maintained in captivity at around 20 individuals for over 75 yr, while many wild African lion populations have become extinct. In order to understand the molecular features of this unique population, we conducted a whole-genome sequencing study on 15 Addis Ababa lions and detected 4.5 million distinct genomic variants compared with the reference African lion genome. Using functional annotation, we identified several genes with mutations that potentially impact various traits such as mane color, body size, reproduction, gastrointestinal functions, cardiovascular processes, and sensory perception. These findings offer valuable insights into the genetics of this threatened lion population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leones Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leones Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido