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Optical genomic mapping is a helpful tool for detecting CCND1 rearrangements in CD5-negative small B-cell lymphoma: Two cases of leukemic non-nodal mantle cell lymphoma.
Quesada, Andres E; Hu, Shimin; Li, Shaoying; Toruner, Gokce A; Wei, Qing; Loghavi, Sanam; Ok, Chi Young; Jain, Preetesh; Thakral, Beenu; Nwogbo, O Valentine; Kim, Do; Iyer, Swaminathan P; You, M James; Medeiros, L Jeffrey; Tang, Guilin.
Afiliación
  • Quesada AE; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. Electronic address: aquesada@mdanderson.org.
  • Hu S; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Li S; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Toruner GA; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Wei Q; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Loghavi S; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Ok CY; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Jain P; Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Thakral B; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Nwogbo OV; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Kim D; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Iyer SP; Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • You MJ; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Medeiros LJ; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Tang G; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Hum Pathol ; 144: 71-76, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38301962
ABSTRACT
Optical genome mapping (OGM) is a new DNA-based technology which provides comprehensive examination of the entire genome. We report two patients who presented with splenomegaly and leukocytosis with lymphocytosis including villous lymphocytes. Neither patient had lymphadenopathy. Bone marrow evaluation showed involvement by small B-cell lymphoma in a sinusoidal and interstitial distribution, and immunophenotypic analysis showed that the neoplastic cells were positive for B-cell markers and cyclin D1 but were negative for SOX11 and CD5. Initially, the clinicopathologic features in both patients were thought to be suspicious for hairy cell leukemia variant or splenic marginal zone lymphoma. However, OGM detected CCND1 rearrangement t(2;11)/IGKCCND1 in one case and t(11;14)/IGHCCND1 in the other case. These cases illustrate the valuable role OGM can play in establishing the diagnosis of MCL. Case 1 also contributes to the paucity of literature on the rare occurrence of IGKCCND1 in MCL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Linfoma de Células B / Linfoma de Células del Manto Límite: Adult / Humans Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Linfoma de Células B / Linfoma de Células del Manto Límite: Adult / Humans Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos