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Efficacy and Safety of Glucagon-Like Peptide 1 Agonists in a Retrospective Study of Patients With Familial Partial Lipodystrophy.
Foss-Freitas, Maria C; Imam, Salman; Neidert, Adam; Gomes, Anabela Dill; Broome, David T; Oral, Elif A.
Afiliación
  • Foss-Freitas MC; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI.
  • Imam S; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI.
  • Neidert A; Mercy Health Anderson Hospital (Family Medicine Residency), Cincinnati, OH.
  • Gomes AD; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI.
  • Broome DT; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI.
  • Oral EA; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI.
Diabetes Care ; 47(4): 653-659, 2024 Apr 01.
Article en En | MEDLINE | ID: mdl-38300898
ABSTRACT

OBJECTIVE:

Glucagon-like peptide 1 receptor agonists (GLP-1RA) are widely used for the management of diabetes mellitus (DM), but their efficacy in familial partial lipodystrophy (FPLD) is unknown. In this retrospective study, we evaluated the effect of GLP-1RA in patients with FPLD. RESEARCH DESIGN AND

METHODS:

We analyzed data, reported with SDs, from 14 patients with FPLD (aged 58 ± 12 years; 76.47% female) and 14 patients with type 2 DM (aged 58 ± 13 years; 71% female) before and 6 months after starting GLP-1RA.

RESULTS:

We observed reduction in weight (95 ± 23 to 91 ± 22 kg; P = 0.002), BMI (33 ± 6 to 31 ± 6 kg/m2; P = 0.001), HbA1c (8.2% ± 1.4% to 7.7% ± 1.4%; P = 0.02), and fasting glucose (186 ± 64 to 166 ± 53 mg/dL; P = 0.04) in patients with FPLD. The change in triglycerides after treatment was greater in the FPLD group compared with the DM group (P = 0.02). We noted acute pancreatitis in two case subjects with FPLD with longer therapy.

CONCLUSIONS:

Our study demonstrates the relative safety and effectiveness of GLP-1RA in patients with FPLD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Diabetes Mellitus Tipo 2 / Lipodistrofia Parcial Familiar Tipo de estudio: Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Diabetes Care Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Diabetes Mellitus Tipo 2 / Lipodistrofia Parcial Familiar Tipo de estudio: Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Diabetes Care Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos