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A thyroid adenoma in a pubertal male with thyroxine-binding globulin deficiency.
Kim, Heeyung; Naiki, Yasuhiro; Iwahashi-Odano, Megumi; Narumi, Satoshi; Ito, Koichi; Ishiguro, Akira.
Afiliación
  • Kim H; Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.
  • Naiki Y; Division of Endocrinology and Metabolism, National Center for Child Health and Development, Tokyo, Japan.
  • Iwahashi-Odano M; Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Narumi S; Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Ito K; Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
  • Ishiguro A; Department of Surgery, Ito Hospital, Tokyo, Japan.
Clin Pediatr Endocrinol ; 33(1): 23-26, 2024.
Article en En | MEDLINE | ID: mdl-38299172
ABSTRACT
Complete deficiency of thyroxin-binding globulin (TBG-CD) is not commonly associated with clinical symptoms, and little is known about thyroid tumors associated with TBG-CD. We present a case report of an asymptomatic follicular adenoma that spontaneously shrank in a patient with TBG-CD. A previously healthy 13-yr-old male presented with a diffusely swollen thyroid gland. Thyroid function tests revealed low total thyroxin and TBG concentrations, indicating a TBG deficiency. Ultrasonography revealed a mildly swollen thyroid gland with a nodule (14 × 12 × 19 mm) in the left lobe. Genetic analysis of peripheral blood revealed a previously reported SERPINA7 variant, which resulted in complete loss of TBG function. The nodule was identified as a follicular adenoma using fine-needle aspiration. Subsequently, the adenoma shrank without treatment. This pubertal case suggests that careful observation with ultrasonography is warranted for follicular adenoma in patients with TBG deficiency and that treatment may not be required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Clin Pediatr Endocrinol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Clin Pediatr Endocrinol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón