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Neuroendocrine carcinoma of the uterine cervix with extensive pagetoid spread pattern.
Sakurai, Azusa; Yamanoi, Koji; Yamaguchi, Ken; Hamanishi, Junzo; Minamiguchi, Sachiko; Mandai, Masaki.
Afiliación
  • Sakurai A; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
  • Yamanoi K; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
  • Yamaguchi K; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
  • Hamanishi J; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
  • Minamiguchi S; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto City, Kyoto, Japan.
  • Mandai M; Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.
J Obstet Gynaecol Res ; 50(4): 758-763, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38297984
ABSTRACT
There have been no reported cases of neuroendocrine carcinoma (NEC) of the cervix with pagetoid spread (Pag-S). A 44-year-old woman came to our department because of abnormal cytology that persisted immediately after a radical hysterectomy for NEC of the cervix. A mapping biopsy in a large area from the vaginal wall to the vulva revealed that synaptophysin/Ki-67-positive tumor cells were scattered within the epithelium in multiple areas, suggesting a wide Pag-S of NEC. Because tumor cells were found beyond the vaginal wall, the anterior pelvic exenteration was performed. Since we could pathologically confirm the complete resection and no distant metastases were detected, no adjuvant therapy was performed. Four years have passed since the initial treatment without any tumor recurrence. It is known that the prognosis of NEC of the cervix that invades beyond the cervix is poor; however, if there is a Pag-S pattern, a radical surgical treatment can be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Carcinoma Neuroendocrino Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Carcinoma Neuroendocrino Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia