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ß-Lactam Susceptibility of Streptococcus dysgalactiae subsp. equisimilis.
Nakashima, Natsumi; Jin, Wanchun; Wachino, Jun-Ichi; Koyama, Shinobu; Tamai, Kiyoko; Arakawa, Yoshichika; Kimura, Kouji.
Afiliación
  • Nakashima N; Department of Bacteriology, Nagoya University Graduate School of Medicine, Japan.
  • Jin W; Department of Bacteriology, Nagoya University Graduate School of Medicine, Japan.
  • Wachino JI; Department of Bacteriology, Nagoya University Graduate School of Medicine, Japan.
  • Koyama S; Miroku Medical Laboratory Inc., Japan.
  • Tamai K; Miroku Medical Laboratory Inc., Japan.
  • Arakawa Y; Department of Bacteriology, Nagoya University Graduate School of Medicine, Japan.
  • Kimura K; Department of Bacteriology, Nagoya University Graduate School of Medicine, Japan.
Jpn J Infect Dis ; 77(4): 236-239, 2024 Jul 23.
Article en En | MEDLINE | ID: mdl-38296542
ABSTRACT
All clinical isolates of Streptococcus dysgalactiae subsp. equisimilis (SDSE) are considered susceptible to ß-lactams, the first-line drugs used to treat SDSE infections. However, given that penicillin-non-susceptible SDSE strains have been isolated in Denmark, in this study, we aimed to identify ß-lactam-non-susceptible clinical isolates of SDSE in Japan. In 2018, we collected 150 clinical isolates of S. dysgalactiae, and species identification was performed using a Rapid ID Strep API kit. The minimum inhibitory concentrations (MIC) of six ß-lactams (penicillin G, oxacillin, ceftizoxime, ceftibuten, cefoxitin, and cefaclor) were determined for the 85 clinical isolates identified as SDSE using the agar dilution method standardized by the Clinical & Laboratory Standards Institute. The MIC ranges of penicillin G, oxacillin, ceftizoxime, ceftibuten, cefoxitin, and cefaclor were 0.007-0.06, 0.03-0.12, 0.015-0.06, 0.25-2, 0.12-2, and 0.06-0.5 µg/mL, respectively. None of the clinical isolates of SDSE were non-susceptible to penicillin G, indicating that all 85 clinical isolates of SDSE were susceptible to ß-lactams. Our findings indicate that almost all clinical isolates of SDSE, from several prefectures of Japan, are still susceptible to ß-lactams. Nevertheless, there remains a need for continuous and careful monitoring of drug susceptibility among clinical SDSE isolates in Japan.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus / Pruebas de Sensibilidad Microbiana / Beta-Lactamas / Antibacterianos Tipo de estudio: Guideline / Prognostic_studies Límite: Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Jpn J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus / Pruebas de Sensibilidad Microbiana / Beta-Lactamas / Antibacterianos Tipo de estudio: Guideline / Prognostic_studies Límite: Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Jpn J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón