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Surface-based Analyses of Diffusional Kurtosis Imaging in Amyotrophic Lateral Sclerosis: Relationship with Onset Subtypes.
Kamiya, Kouhei; Hanashiro, Sayori; Kano, Osamu; Uchida, Wataru; Kamagata, Koji; Aoki, Shigeki; Hori, Masaaki.
Afiliación
  • Kamiya K; Department of Radiology, Faculty of Medicine, Toho University, Tokyo, Japan.
  • Hanashiro S; Department of Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Kano O; Department of Neurology, Faculty of Medicine, Toho University, Tokyo, Japan.
  • Uchida W; Department of Neurology, Faculty of Medicine, Toho University, Tokyo, Japan.
  • Kamagata K; Department of Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Aoki S; Department of Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
  • Hori M; Department of Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Magn Reson Med Sci ; 2024 Jan 30.
Article en En | MEDLINE | ID: mdl-38296522
ABSTRACT

PURPOSE:

Here, we aimed to characterize the cortical and subcortical microstructural alterations in the brains of patients with amyotrophic lateral sclerosis (ALS). In particular, we compared these features between bulbar-onset ALS (b-ALS) and limb-onset ALS (l-ALS).

METHODS:

Diffusion MRI data (b = 0, 700, 2000 ms/mm2, 1.7-mm isotropic voxel) from 28 patients with ALS (9 b-ALS and 19 l-ALS) and 17 healthy control subjects (HCs) were analyzed. Diffusional kurtosis imaging (DKI) metrics were sampled at the mid-cortical and subcortical surfaces. We used permutation testing with a nonparametric combination of mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) to assess intergroup differences over the cerebrum. We also carried out an atlas-based analysis focusing on Brodmann Area 4 and 6 (primary motor and premotor areas) and investigated the correlation between MRI metrics and clinical parameters.

RESULTS:

At both the mid-cortical and subcortical surfaces, b-ALS was associated with significantly greater MD, smaller FA, and smaller MK in the motor and premotor areas than HC. In contrast, the patients with l-ALS showed relatively moderate differences relative to HCs. The ALS Functional Rating Scale-Revised bulbar subscore was significantly correlated with the diffusion metrics in Brodmann Area 4.

CONCLUSION:

The distribution of abnormalities over the cerebral hemispheres and the more severe microstructural alteration in b-ALS compared to l-ALS were in good agreement with findings from postmortem histology. Our results suggest the feasibility of surface-based DKI analyses for exploring brain microstructural pathologies in ALS. The observed differences between b-ALS and l-ALS and their correlations with functional bulbar impairment support the clinical relevance of DKI measurement in the cortical and juxtacortical regions of patients with ALS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Magn Reson Med Sci Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Magn Reson Med Sci Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón