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Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles.
Alkon-Meadows, Tamar; Hernandez-Nieto, Carlos; Jackson-Bey, Tia; Cacchione, Teresa A; Lee, Joseph; Luna-Rojas, Martha; Gounko, Dmitry; Copperman, Alan; Buyuk, Erkan.
Afiliación
  • Alkon-Meadows T; Reproductive Medicine Associates of New York, New York, NY, USA. tamar.alkon@rmamexico.com.
  • Hernandez-Nieto C; Reproductive Medicine Associates of New York, New York, NY, USA.
  • Jackson-Bey T; Reproductive Medicine Associates of New York, New York, NY, USA.
  • Cacchione TA; Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Lee J; Reproductive Medicine Associates of New York, New York, NY, USA.
  • Luna-Rojas M; Reproductive Medicine Associates of New York, New York, NY, USA.
  • Gounko D; Reproductive Medicine Associates of New York, New York, NY, USA.
  • Copperman A; Reproductive Medicine Associates of New York, New York, NY, USA.
  • Buyuk E; Reproductive Medicine Associates of New York, New York, NY, USA.
J Assist Reprod Genet ; 41(3): 693-702, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38294622
ABSTRACT

PURPOSE:

To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds.

METHODS:

This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among different racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.

RESULTS:

Five thousand five hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy rates when compared to their counterparts (p ≤ 0.0001). However, after controlling for confounding factors, there was no association between race and the odds of having  a higher euploidy rate (aOR 1.31; 95% CI 0.63-2.17, p = 0.42). A total of 4949 patients underwent SEET. Pregnancy outcomes did not differ among patients of varying self-reported races.

CONCLUSIONS:

Euploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tasa de Natalidad / Diagnóstico Preimplantación Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tasa de Natalidad / Diagnóstico Preimplantación Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos