Your browser doesn't support javascript.
loading
Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata.
Zheng, Xue-Yong; Ma, Yan-Ping; Zhang, Bo; Chen, Yan-Xin; Tang, Lei; Tai, Xiao-Hua; Cao, Jia-Hao.
Afiliación
  • Zheng XY; Department of Thyroid Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • Ma YP; Department of Endoscopic Center, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • Zhang B; Department of Thyroid Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • Chen YX; Department of Thyroid Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • Tang L; Department of Thyroid Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • Tai XH; Department of Thyroid Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • Cao JH; Department of Thyroid Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Front Endocrinol (Lausanne) ; 14: 1309620, 2023.
Article en En | MEDLINE | ID: mdl-38292771
ABSTRACT

Background:

Although observational studies have found an association between hypothyroidism and alopecia areata, the causality of this relationship remains unclear.

Objectives:

This study aimed to investigate the genetic variants associated with hypothyroidism and their potential impact on the risk of developing alopecia areata.

Methods:

genome-wide association study summary statistics for hypothyroidism (30,155 cases and 379,986 controls) and alopecia areata (289 cases and 211,139 controls) were obtained from the IEU OpenGwas project. The inverse variance-weighted method was used as the primary analysis method to evaluate the causality between hypothyroidism and alopecia areata, supplemented by the weighted median, MR-Egger, simple mode and weighted mode. Furthermore, the function of causal SNPs was evaluated by gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction networks.

Result:

Utilizing two-sample Mendelian randomization analysis, we found that the single-nucleotide polymorphisms (SNPs) of hypothyroidism (OR = 1.40, 95% CI 1.12-1.75, p = 3.03×10-3) significantly increased the risk of alopecia areata ( 289 cases and 211,139 controls ). KEGG pathway analysis showed that the candidate genes were mainly enriched in virion-herpesvirus, Th1 and Th2 cell differentiation, Th17 cell differentiation, T-cell receptor signaling pathway, PD-L1/PD-1 checkpoint pathway in cancer and Toll-like receptor signaling pathway. Protein-protein interaction networks results showed that CTLA4, STAT4, IL2RA, TYK2, IRF7, SH2B3, BACH2, TLR3, NOD2, and FLT3.

Conclusion:

This study provided compelling genetic evidence supporting a causative association between hypothyroidism and alopecia areata, which could potentially inform the development of more efficacious treatment strategies for patients afflicted by alopecia areata.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alopecia Areata / Hipotiroidismo Tipo de estudio: Clinical_trials / Observational_studies Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alopecia Areata / Hipotiroidismo Tipo de estudio: Clinical_trials / Observational_studies Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza