Your browser doesn't support javascript.
loading
Automatic lung segmentation of magnetic resonance images: A new approach applied to healthy volunteers undergoing enhanced Deep-Inspiration-Breath-Hold for motion-mitigated 4D proton therapy of lung tumors.
Missimer, John H; Emert, Frank; Lomax, Antony J; Weber, Damien C.
Afiliación
  • Missimer JH; Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
  • Emert F; Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
  • Lomax AJ; Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
  • Weber DC; Department of Physics, ETH Zurich, Zurich, Switzerland.
Phys Imaging Radiat Oncol ; 29: 100531, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38292650
ABSTRACT
Background and

purpose:

Respiratory suppression techniques represent an effective motion mitigation strategy for 4D-irradiation of lung tumors with protons. A magnetic resonance imaging (MRI)-based study applied and analyzed methods for this purpose, including enhanced Deep-Inspiration-Breath-Hold (eDIBH). Twenty-one healthy volunteers (41-58 years) underwent thoracic MR scans in four imaging sessions containing two eDIBH-guided MRIs per session to simulate motion-dependent irradiation conditions. The automated MRI segmentation algorithm presented here was critical in determining the lung volumes (LVs) achieved during eDIBH. Materials and

methods:

The study included 168 MRIs acquired under eDIBH conditions. The lung segmentation algorithm consisted of four analysis

steps:

(i) image preprocessing, (ii) MRI histogram analysis with thresholding, (iii) automatic segmentation, (iv) 3D-clustering. To validate the algorithm, 46 eDIBH-MRIs were manually contoured. Sørensen-Dice similarity coefficients (DSCs) and relative deviations of LVs were determined as similarity measures. Assessment of intrasessional and intersessional LV variations and their differences provided estimates of statistical and systematic errors.

Results:

Lung segmentation time for 100 2D-MRI planes was âˆ¼ 10 s. Compared to manual lung contouring, the median DSC was 0.94 with a lower 95 % confidence level (CL) of 0.92. The relative volume deviations yielded a median value of 0.059 and 95 % CLs of -0.013 and 0.13. Artifact-based volume errors, mainly of the trachea, were estimated. Estimated statistical and systematic errors ranged between 6 and 8 %.

Conclusions:

The presented analytical algorithm is fast, precise, and readily available. The results are comparable to time-consuming, manual segmentations and other automatic segmentation approaches. Post-processing to remove image artifacts is under development.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Phys Imaging Radiat Oncol Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Phys Imaging Radiat Oncol Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Países Bajos