Your browser doesn't support javascript.
loading
Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease.
Marshall, J P S; Huynh, K; Lancaster, G I; Ng, J; Collins, J M; Pernes, G; Liang, A; Featherby, T; Mellet, N A; Drew, B G; Calkin, A C; King, A E; Meikle, P J; Febbraio, M A; Adlard, P A; Henstridge, D C.
Afiliación
  • Marshall JPS; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Huynh K; School of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.
  • Lancaster GI; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.
  • Ng J; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Collins JM; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, Australia.
  • Pernes G; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, VIC, Australia.
  • Liang A; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Featherby T; Department of Immunology, Monash University, Melbourne, VIC, Australia.
  • Mellet NA; School of Health Sciences, The University of Tasmania, Launceston, TAS, Australia.
  • Drew BG; Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.
  • Calkin AC; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • King AE; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Meikle PJ; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.
  • Febbraio MA; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Adlard PA; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Henstridge DC; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, Australia.
iScience ; 27(2): 108800, 2024 Feb 16.
Article en En | MEDLINE | ID: mdl-38292430
ABSTRACT
Alzheimer's disease (AD) is associated with both extracellular amyloid-ß (Aß) plaques and intracellular tau-containing neurofibrillary tangles (NFT). We characterized the behavioral, metabolic and lipidomic phenotype of the 5xFADxTg30 mouse model which contains overexpression of both Aß and tau. Our results independently reproduce several phenotypic traits described previously for this model, while providing additional characterization. This model develops many aspects associated with AD including frailty, decreased survival, initiation of aspects of cognitive decline and alterations to specific lipid classes and molecular lipid species in the plasma and brain. Notably, some sex-specific differences exist in this model and motor impairment with aging in this model does compromise the utility of the model for some movement-based behavioral assessments of cognitive function. These findings provide a reference for individuals interested in using this model to understand the pathology associated with elevated Aß and tau or for testing potential therapeutics for the treatment of AD.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos