Your browser doesn't support javascript.
loading
Expression levels of key immune indicators and immune checkpoints in manganese-exposed rats.
Qi, Yuanmeng; Si, Huifang; Jin, Xiaofei; Guo, Yonghua; Xia, Jiarui; He, Jing; Deng, Xuedan; Deng, Meng; Yao, Wu; Hao, Changfu.
Afiliación
  • Qi Y; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China.
  • Si H; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China; Prevention and Infection Control Section, Xi'an Union Hospital, 710199 Xi'an, Shaanxi Province, China.
  • Jin X; Department of Ultrasound, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450015 Henan, China.
  • Guo Y; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China.
  • Xia J; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China.
  • He J; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China.
  • Deng X; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China.
  • Deng M; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China.
  • Yao W; Department of Occupational and Environment Health, College of Public Health, Zhengzhou University, 450001 Henan, China. Electronic address: yaowu@zzu.edu.cn.
  • Hao C; Department of Child and Adolescence Health, College of Public Health, Zhengzhou University, 450001 Henan, China. Electronic address: haochangfu@126.com.
Ecotoxicol Environ Saf ; 272: 116029, 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38290312
ABSTRACT
Manganese is essential trace elements, to participate in the body a variety of biochemical reactions, has important physiological functions, such as stimulate the immune cell proliferation, strengthen the cellular immunity, etc. However, excessive manganese exposure can cause damage to multiple systems of the body.The immune system is extremely vulnerable to external toxicants, however manganese research on the immune system are inadequate and biomarkers are lacking. Therefore, here we applied a manganese-exposed rat model to make preliminary observations on the immunotoxic effects of manganese. We found that manganese exposure inhibited humoral immune function in rats by decreasing peripheral blood IgG (ImmunoglobulinG, IgG), IgM (ImmunoglobulinM, IgM) and complement C3 levels; It also regulates rat cellular immune activity by influencing peripheral blood, spleen, and thymus T cell numbers and immune organ ICs (Immune Checkpoints, ICs) and cytokine expression. Furthermore, it was revealed that the impact of manganese exposure on the immune function of rats exhibited a correlation with both the dosage and duration of exposure. Notably, prolonged exposure to high doses of manganese had the most pronounced influence on rat immune function, primarily manifesting as immunosuppression.The above findings suggest that manganese exposure leads to impaired immune function and related changes in immune indicators, or may provide clues for the discovery of its biomarkers.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Manganeso Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Manganeso Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos