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Improving rodents and humans cardiac cell maturityin vitrothrough polycaprolactone and polyurethane nanofibers.
Iwon, Zuzanna; Krogulec, Ewelina; Kierlanczyk, Aleksandra; Baranowska, Patrycja; Lopianiak, Iwona; Wojasinski, Michal; Jastrzebska, Elzbieta.
Afiliación
  • Iwon Z; Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland.
  • Krogulec E; Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
  • Kierlanczyk A; Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland.
  • Baranowska P; Centre for Advanced Materials and Technologies, CEZAMAT Warsaw University of Technology, Warsaw, Poland.
  • Lopianiak I; Department of Biotechnology and Bioprocess Engineering, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland.
  • Wojasinski M; Department of Biotechnology and Bioprocess Engineering, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland.
  • Jastrzebska E; Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland.
Biomed Mater ; 19(2)2024 Feb 12.
Article en En | MEDLINE | ID: mdl-38290152
ABSTRACT
Currently, numerous studies are conducted using nanofibers as a scaffold for culture cardiac cells; however, there still needs to be more research evaluating the impact of the physicochemical properties of polymer nanofibers on the structure and function of cardiac cells. We have studied how poly(ϵ-caprolactone) and polyurethane nanofibrous mats with different physicochemical properties influence the viability, morphology, orientation, and maturation of cardiac cells. For this purpose, the cells taken from different species were used. They were rat ventricular cardiomyoblasts (H9c2), mouse atrial cardiomyocytes (CMs) (HL-1), and human ventricular CMs. Based on the results, it can be concluded that cardiac cells cultured on nanofibers exhibit greater maturity in terms of orientation, morphology, and gene expression levels compared to cells cultured on polystyrene plates. Additionally, the physicochemical properties of nanofibers affecting the functionality of cardiac cells from different species and different parts of the heart were evaluated. These studies can support research on understanding and explaining mechanisms leading to cellular maturity present in the heart and the selection of nanofibers that will effectively help the maturation of CMs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Andamios del Tejido / Nanofibras Límite: Animals / Humans Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Andamios del Tejido / Nanofibras Límite: Animals / Humans Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido