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Respiratory sarcopenia screening in dialysis patients: cross-sectional and multicentre study protocol.
Andrade, Francini Porcher; Borges, Sheila; da Silva Filho, César Alencar; Martins, Taís Ferreira; Benvenutti, Heloíse; de Freitas, Júlia de Melo Cardoso; Thomé, Fernando Saldanha; Karohl, Cristina; Souza, Gabriela Correa; Cipriano, Graziella França Bernardelli; Rovedder, Paula Maria Eidt.
Afiliación
  • Andrade FP; Ciências Pneumológicas Post-Graduation Programme, Federal University of Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2400 2º andar, Porto Alegre, RS, 90035-003, Rio Grande do Sul, Brazil. fran_porcher@hotmail.com.
  • Borges S; Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil. fran_porcher@hotmail.com.
  • da Silva Filho CA; Research Center in Sports Sciences, Health Sciences and Human Development, University of Maia (CIDESD-UMAIA), Maia, Portugal. fran_porcher@hotmail.com.
  • Martins TF; Science and Technology in Health Programme, University of Brasília (UnB), Brasília, Distrito Federal, Brazil.
  • Benvenutti H; Ciências Pneumológicas Post-Graduation Programme, Federal University of Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2400 2º andar, Porto Alegre, RS, 90035-003, Rio Grande do Sul, Brazil.
  • de Freitas JMC; Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.
  • Thomé FS; Sciences of Rehabilitation Post-Graduation Programme, University of Brasília (UnB), Brasilia, Distrito Federal, Brazil.
  • Karohl C; Ciências Pneumológicas Post-Graduation Programme, Federal University of Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2400 2º andar, Porto Alegre, RS, 90035-003, Rio Grande do Sul, Brazil.
  • Souza GC; Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.
  • Cipriano GFB; Medical Sciences Focused on Endocrinology Post-Graduation Programme, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
  • Rovedder PME; Faculty of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
BMC Nephrol ; 25(1): 41, 2024 Jan 29.
Article en En | MEDLINE | ID: mdl-38287281
ABSTRACT

BACKGROUND:

Respiratory sarcopenia is characterized by the weakness of respiratory muscles associated with sarcopenia due to aging or systemic diseases such as chronic kidney disease (CKD). Patients with CKD undergoing dialysis are particularly susceptible to respiratory muscle weakness caused by factors such as fluid overload and electrolyte imbalance. This weakness not only affects ventilation but also impairs oxygen uptake and delivery to muscle tissue, potentially leading to severe sarcopenia. Thus, the objective of this study is to conduct a respiratory sarcopenia screening in patients with CKD undergoing haemodialysis (HD) and peritoneal dialysis (PD).

METHODS:

This is an observational, cross-sectional and multicentre study conducted between March 2023 and March 2025. The study was approved by the Research Ethics Committee at two centres. Sarcopenia diagnosis is determined based on low handgrip strength and amount of appendicular skeletal muscle mass, assessed through bioelectrical impedance analysis. Respiratory sarcopenia is diagnosed in patients with sarcopenia who have low inspiratory muscle strength, evaluated through a manovacuometry test. The severity of sarcopenia and respiratory sarcopenia is defined, respectively, by low physical performance (measured using the Short Physical Performance Battery and Timed-Up and Go test) and pulmonary performance (measured through spirometry). Thus, this study will include 81 patients undergoing dialysis (41 on HD and 40 on PD) from three participating centres.

DISCUSSION:

The literature has been focused on respiratory function in CKD; however, the relationship with sarcopenia remains understudied. We believe that, similar to appendicular skeleton muscles, the axial skeleton muscles are also likely to weaken with the presence of chronic disease, such as CKD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Sarcopenia Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Aspecto: Ethics Límite: Humans Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Sarcopenia Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Aspecto: Ethics Límite: Humans Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido